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Titolo:
Increased novelty seeking and decreased harm avoidance in rats showing type 2-like behaviour following basal forebrain neuronal loss
Autore:
Johansson, AK; Hansen, S;
Indirizzi:
Gothenburg Univ, Dept Psychol, SE-40530 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden
Titolo Testata:
ALCOHOL AND ALCOHOLISM
fascicolo: 6, volume: 36, anno: 2001,
pagine: 520 - 524
SICI:
0735-0414(200111/12)36:6<520:INSADH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; VENTRAL STRIATUM; NUCLEUS-ACCUMBENS; ALCOHOL-CONSUMPTION; LESIONS; PERSONALITY; ANXIETY; SEROTONIN; MODEL; DISINHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Hansen, S Gothenburg Univ, Dept Psychol, Box 500, SE-40530 Gothenburg, Sweden Gothenburg Univ Box 500 Gothenburg Sweden SE-40530 burg, Sweden
Citazione:
A.K. Johansson e S. Hansen, "Increased novelty seeking and decreased harm avoidance in rats showing type 2-like behaviour following basal forebrain neuronal loss", ALC ALCOHOL, 36(6), 2001, pp. 520-524

Abstract

Previous research ha, shown that excitotoxic lesions of the septum, ventral striatum and adjacent areas increase alcohol intake and defensive aggression in the rat. This behavioural constellation resembles that observed in early-onset Type 2 alcoholism. Due to the fact that the prototypical Type 2 alcoholic scores high on novelty seeking and low on harm avoidance, we studied these temperamental traits in rats with basal forebrain lesions. In comparison with controls, such rats showed more exploration (nose-poking) of ahole-board (indicating increased novelty seeking) and less risk assessmentbehaviour (stretched attend Posturing) in an unfamiliar arena (indicating reduced harm avoidance). In both tests the experimental rats showed signs of motor restlessness, The results obtained indicate that basal forebrain neuronal loss may be associated with an enhanced exploratory responsiveness to novel stimuli together with a relative freedom of anticipatory anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:51:04