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Titolo:
Approach to setting occupational exposure limits for sensory irritants in the Netherlands
Autore:
Feron, VJ; Arts, JHE; Mojet, J;
Indirizzi:
TNO, Nutr & Food Res Inst, Dept Gen Toxicol, Div Toxicol, NL-3700 AJ Zeist, Netherlands TNO Zeist Netherlands NL-3700 AJ Toxicol, NL-3700 AJ Zeist, Netherlands TNO, Nutr & Food Res Inst, Dept Target Organ Toxicol, NL-3700 AJ Zeist, Netherlands TNO Zeist Netherlands NL-3700 AJ Toxicol, NL-3700 AJ Zeist, Netherlands TNO, Nutr & Food Res Inst, Dept Food Sci & Technol, NL-3700 AJ Zeist, Netherlands TNO Zeist Netherlands NL-3700 AJ Technol, NL-3700 AJ Zeist, Netherlands
Titolo Testata:
AIHAJ
fascicolo: 6, volume: 62, anno: 2001,
pagine: 733 - 735
SICI:
1529-8663(200111/12)62:6<733:ATSOEL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTH SYMPTOMS; PERCEIVED ODOR; SENSITIVITY; IRRITATION; ACETONE;
Keywords:
health-based recommended occupational exposure limit; Netherlands; odor and sensory irritation thresholds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Feron, VJ TNO, Nutr & Food Res Inst, Dept Gen Toxicol, Div Toxicol, POB 360, NL-3700AJ Zeist, Netherlands TNO POB 360 Zeist Netherlands NL-3700 AJ 0AJ Zeist, Netherlands
Citazione:
V.J. Feron et al., "Approach to setting occupational exposure limits for sensory irritants in the Netherlands", AIHAJ, 62(6), 2001, pp. 733-735

Abstract

This article describes how scientists in the Netherlands set occupational exposure limits (OELs) for sensory irritants. When they tackle this issue, a number of key questions need to be answered. For example, did the studiesindeed measure sensory irritation and not cytotoxicity? When the irritant is an odorant, can interference of olfactory stimulation be excluded? In the case of subjective measurements, can psychological irritation be excluded? When adaptation is an issue, did the studies indeed measure adaptation and not habituation? When OELs are established in the Netherlands, each of these issues is carefully addressed before a value is suggested. When settingan OEL in the Netherlands, human data carry more weight than animal data of comparable quality. As in the United States, documentation for the recommended OEL is written and a discussion of all available relevant and reliable data culminating in the selection of the key study for deriving the health-based recommended occupational exposure limit is provided. Special effortis dedicated to reconciling differences between the animal and human data. If the toxicological database is considered to be inadequate, the committee acknowledges this limitation and will not recommend a limit value due to insufficient data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:03:25