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Titolo:
Evaluating the human response to sensory irritation: Implications for setting occupational exposure limits
Autore:
Dalton, P;
Indirizzi:
Monell Chem Senses Ctr, Philadelphia, PA 19104 USA Monell Chem Senses CtrPhiladelphia PA USA 19104 iladelphia, PA 19104 USA
Titolo Testata:
AIHAJ
fascicolo: 6, volume: 62, anno: 2001,
pagine: 723 - 729
SICI:
1529-8663(200111/12)62:6<723:ETHRTS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN NASAL-MUCOSA; HEALTH SYMPTOMS; CHEMICAL-EXPOSURE; PERCEIVED ODOR; THRESHOLDS; CHALLENGE; PUNGENCY; ACETONE;
Keywords:
electrophysiological assessments; odor; psychophysical assessments; exposure methods; sensory irritation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dalton, P Monell Chem Senses Ctr, 3500 Market St, Philadelphia, PA 19104 USA Monell Chem Senses Ctr 3500 Market St Philadelphia PA USA 19104
Citazione:
P. Dalton, "Evaluating the human response to sensory irritation: Implications for setting occupational exposure limits", AIHAJ, 62(6), 2001, pp. 723-729

Abstract

Although animal models of sensory irritation have led to the development of useful assays for evaluating the potency of chemical irritants, the importance of conducting human exposure studies to model and understand the human response to sensory irritants cannot be minimized. In recent years a series of tests have been developed for humans that can be safely conducted andthat can provide excellent data on which to base occupational exposure limits. This article delineates the major issues involved in the evaluations of sensory irritation in humans, Among these issues are the differences between odor and irritation, irritation and slight toxicity, adaptation and habituation, as well as personal expectation about discomfort and the reportedirritation. The article also describes psychophysiological and electrophysiological methods for assessing sensory irritation, Some of the possible confounders that can influence the results of human tests involving sensory irritants are addressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:58:58