Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Similarities and differences in semantic and phonological processing with age: Patterns of functional MRI activation
Autore:
Johnson, SC; Saykin, AJ; Flashman, LA; McAllister, TW; OJile, JR; Sparling, MB; Guerin, SJ; Moritz, CH; Mamourian, AC;
Indirizzi:
Dartmouth Coll Sch Med, DHMC, Brain Imaging Lab, Dept Psychiat, Lebanon, NH 03756 USA Dartmouth Coll Sch Med Lebanon NH USA 03756 ychiat, Lebanon, NH 03756 USA Dartmouth Coll Sch Med, Dept Radiol, Brain Imaging Lab, Lebanon, NH 03756 USA Dartmouth Coll Sch Med Lebanon NH USA 03756 ng Lab, Lebanon, NH 03756 USA New Hampshire Hosp, Concord, NH USA New Hampshire Hosp Concord NH USANew Hampshire Hosp, Concord, NH USA
Titolo Testata:
AGING NEUROPSYCHOLOGY AND COGNITION
fascicolo: 4, volume: 8, anno: 2001,
pagine: 307 - 320
SICI:
1382-5585(200112)8:4<307:SADISA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR PREFRONTAL CORTEX; EVENT-RELATED FMRI; NEUROIMAGING ANALYSES; ALZHEIMERS-DISEASE; BRAIN ACTIVATION; NAMING ABILITY; WORKING-MEMORY; VOLUMES; CONJUNCTION; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Saykin, AJ Dartmouth Coll Sch Med, DHMC, Brain Imaging Lab, Dept Psychiat,1 Med Ctr Dr, Lebanon, NH 03756 USA Dartmouth Coll Sch Med 1 Med Ctr Dr Lebanon NH USA 03756 56 USA
Citazione:
S.C. Johnson et al., "Similarities and differences in semantic and phonological processing with age: Patterns of functional MRI activation", AGING NEURO, 8(4), 2001, pp. 307-320

Abstract

In this investigation, we analyzed the effect of age on fMRI activation during semantic and phonological decision tasks using whole-brain echo-planarimaging. Nine right-handed healthy younger adults were compared to nine right-handed healthy older adult volunteers. While undergoing fMRI scanning, subjects completed three functional MRI auditory stimulation tasks requiring semantic or phonological decisions (match/mismatch) about word pairs (category -exemplar, category -function, pseudo-word). Performance scores on these tasks did not differ between age groups. The fMRI images were motion corrected, spatially normalized, and statistically analyzed for group similarities and differences using a random-effects model. For the semantic tasks,both older and younger adults showed activity within the inferior frontal gyrus (left more than right) and left superior temporal gyrus, whereas small regional age differences (younger > older) were found in the left inferior precentral region. For the phonologic task, common areas of activation were found in the superior temporal gyrus (left more than right). Age-relateddifferences in the phonologic task were observed predominantly in the right angular region. The results were not changed by entry of a quantitative atrophy index as a covariate. These findings highlight the similarities in semantic processing across age groups and suggest that global age related atrophy is not impacting activation significantly in healthy older adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:22