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Titolo:
Two-generation reproductive toxicity study of tributyltin chloride in malerats
Autore:
Omura, M; Ogata, R; Kubo, K; Shimasaki, Y; Aou, S; Oshima, Y; Tanaka, A; Hirata, M; Makita, Y; Inoue, N;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Hyg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Hyg, Fukuoka 8128582, Japan Japan Sci & Technol Corp, CREST, Res Area, Kawaguchi, Saitama 3320012, Japan Japan Sci & Technol Corp Kawaguchi Saitama Japan 3320012 a 3320012, Japan Kyushu Univ, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 tegrat Physiol, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch,Inst Marine Biol Chem, Dept Biosci & Biotechnol,Lab Marine Environm Sci, Div Bioresource & Bioenvironm Sci, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 ioenvironm Sci, Fukuoka 8128581, Japan
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 64, anno: 2001,
pagine: 224 - 232
SICI:
1096-6080(200112)64:2<224:TRTSOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE COMPOUNDS EACS; I SCREENING BATTERY; AROMATASE INHIBITOR; PROSTATIC HYPERPLASIA; TESTICULAR FUNCTION; ESTROGEN REGULATION; ANDROGEN RECEPTOR; FEED RESTRICTION; SPERMATOGENESIS; ANTIESTROGEN;
Keywords:
tributyltin chloride; 2-generation reproductive toxicity study; male reproductive toxicity; ventral prostate; 17 beta-estradiol; aromatase inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Omura, M Kyushu Univ, Grad Sch Med Sci, Dept Hyg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 t Hyg, Fukuoka 8128582, Japan
Citazione:
M. Omura et al., "Two-generation reproductive toxicity study of tributyltin chloride in malerats", TOXICOL SCI, 64(2), 2001, pp. 224-232

Abstract

A 2-generation reproductive toxicity study of tributyltin chloride (TBTCl)was conducted in male rats using dietary concentrations of 5, 25, and 125 ppm TBTCl to evaluate its effect on sexual development and the reproductivesystem. Fl males were killed on postnatal day 119 and F2 males were killedon postnatal day 91. TBTCl affected the male reproductive system of rats. The weights of the testis and epididymis were decreased and homogenization-resistant spermatid and sperm count were reduced mainly in the 125 ppm TBTCl group. Histopathologic changes were also observed in the testis of this group and included vacuolization of the seminiferous epithelium, spermatid retention, and delayed spermiation. However, the changes were minimal in nature. The weight of the ventral prostate was decreased to 84% of the controlvalue in the 125 ppm group in the F1 generation and decreased to 84 and 69% of the control value in the 25 ppm and 125 ppm TBTCl groups, respectively, in the F2 generation. The serum 17 beta -estradiol concentration was alsodecreased to 55% of the control value in the 125 ppm group in the F1 generation and decreased to 78 and 57% of the control value in the 25 ppm and 125 ppm TBTCl groups, respectively, in the F2 generation. However, the serum concentrations of luteinizing hormone (LH) and testosterone were not decreased in these groups. These changes corresponded with those caused by aromatase inhibition and therefore TBTCl might be a weak aromatase inhibitor in male rats.

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Documento generato il 30/11/20 alle ore 23:55:19