Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor
Autore:
Purkerson-Parker, S; McDaniel, KL; Moser, VC;
Indirizzi:
Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 xicol, Chapel Hill, NC 27599 USA US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 & Dev, Res Triangle Pk, NC 27711 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 64, anno: 2001,
pagine: 216 - 223
SICI:
1096-6080(200112)64:2<216:DTBITR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 MAZINDOL BINDING; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; UPTAKE SITES; MICE LACKING; BRAIN; NEURONS; RECEPTORS; INSECTICIDES; TOXICITY;
Keywords:
heptachlor; dieldrin; dopamine transporter; neurotoxicity; developmental; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Moser, VC US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, NTD MD-74B, Res Triangle Pk, NC 27711 USA US EPA NTD MD-74B Res Triangle Pk NC USA 27711 Pk, NC 27711 USA
Citazione:
S. Purkerson-Parker et al., "Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor", TOXICOL SCI, 64(2), 2001, pp. 216-223

Abstract

Heptachlor is a persistent cyclodiene pesticide that affects GABAergic function. Recent reports indicate that heptachlor exposure also alters dopamine transporter (DAT) expression and function in adult mice. The aim of this study was to determine whether gestational, perinatal, and/or adolescent heptachlor exposure in rats altered dopamine-receptor and DAT binding. Adolescent exposure to dieldrin was included to evaluate the generality of the findings. Sprague-Dawley rats received doses (po) ranging from 0 to 8.4 mg/kg/day of heptachlor, or dieldrin, 3 mg/kg/day, during different developmental periods. There were dose-related decreases in maternal weight gain and pup survival, as well as delayed righting reflex, at heptachlor doses greaterthan or equal to3 mg/kg/day. There were no changes in striatal dopamine receptor-D1 ([H-3]SCH-23390) and -D2 ([H-3]spiperone) binding in preweanling pups exposed perinatally to heptachlor, and no differences in the response of adult rats to the motor activity-increasing effects of d-amphetamine. However, there were significant (27-64%) increases in striatal DAT binding of[H-3]mazindol in preweanling rats exposed only gestationally. In rats exposed perinatally and/or during adolescence, there were also increases (34-65%) in striatal DAT binding at postnatal days (PND) 22, 43, and 128. Adolescent exposure to dieldrin also increased DAT binding. In other rats exposed perinatally and throughout adolescence, even the lowest dose of heptachlor 0.3 mg/kg/d increased DAT binding on PND 130. The DAT affinity for mazindolwas unchanged in heptachlor-exposed striata. In vitro binding studies indicated that heptachlor (greater than or equal to 10 muM) displaced mazindol binding. Thus, gestational, perinatal, and/or adolescent exposure to heptachlor produced an increase in DAT binding as early as PND 10, and this change persisted into adulthood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:32:14