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Titolo:
Drug monitoring of quinine in men with nonsevere falciparum malaria: Studyin the Amazon region of Brazil
Autore:
Vieira, JLF; Midio, AF;
Indirizzi:
Fed Univ Para, Dept Deontol & Med Legal, BR-66059 Belem, Para, Brazil Fed Univ Para Belem Para Brazil BR-66059 al, BR-66059 Belem, Para, Brazil Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol & Toxicol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil & Toxicol & Toxicol, Sao Paulo, Brazil
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 6, volume: 23, anno: 2001,
pagine: 612 - 615
SICI:
0163-4356(200112)23:6<612:DMOQIM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMALARIAL-DRUGS; PHARMACOKINETICS;
Keywords:
quinine; falciparum malaria; drug monitoring; Amazon region;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Vieira, JLF Av Prof Lineo Prestes 580, BR-05508900 Sao Paulo, Brazil Av Prof Lineo Prestes 580 Sao Paulo Brazil BR-05508900 BCzil
Citazione:
J.L.F. Vieira e A.F. Midio, "Drug monitoring of quinine in men with nonsevere falciparum malaria: Studyin the Amazon region of Brazil", THER DRUG M, 23(6), 2001, pp. 612-615

Abstract

Quinine sulfate has been the drug of choice for the treatment of the ever-increasing number of cases of falciparum malaria in tropical countries. Because of the spectrum of adverse effects produced by the drug in the so-called cinchona syndrome, the variation in its pharmacokinetics during the episodes of falciparum malaria, and the different therapeutic regimens proposedin different countries, the authors monitored quinine plasma concentrations in daily samples of 20 men of the Amazon region in Brazil with nonsevere falciparum malaria who were administered 1 g quinine sulfate every 12 hoursfor 7 days. Three blood samples were collected from each patient each day:two immediately before administration of the drug (7 AM and 7 PM) and one at 11 AM. A total of 440 samples were analyzed by a validated method developed in the authors' laboratories using the high-performance liquid chromatographic technique. The overall quinine plasma levels obtained varied from 1.52 to 16.89 mug/mL. From the second day of treatment, overall levels varied from 2.33 to 14.29 mug/mL: the peak concentrations showed values from 4.22 to 16.89 mug/mL, showing the efficacy of the therapeutic regimen used. Adverse effects (signs and symptoms of cinchonism) were observed in all patients. However, no cases of hypoglycemia were detected. Intrapatient comparisons of the obtained quinine plasma concentrations were statistically significant. The quinine dose may be reduced oil day 4 of treatment when asexual parasitemia is absent. This way, no resistance to the drug is observed, cinchonism can be minimized, and good adherence to the regimen is obtained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:44:45