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Titolo:
Resistance analyses in HIV infected patients with a history of multiple antiretroviral treatment regimens
Autore:
Plettenberg, A; Albrecht, D; Lorenzen, T; Paech, V; Petersen, H; Fenner, T; Meyer, T; Arndt, R; Hertogs, K; Pauwels, R; Weitzel, T; Stoehr, A;
Indirizzi:
Gen Hosp St Georg, Infect Dis Outpatient Dept, Haus Z, D-20099 Hamburg, Germany Gen Hosp St Georg Hamburg Germany D-20099 us Z, D-20099 Hamburg, Germany Labor Fenner & Partner, Hamburg, Germany Labor Fenner & Partner Hamburg Germany nner & Partner, Hamburg, Germany Labor Kesser Arndt & Partner, Hamburg, Germany Labor Kesser Arndt & Partner Hamburg Germany Partner, Hamburg, Germany Virco NV Mechelen, Mechelen, Belgium Virco NV Mechelen Mechelen BelgiumVirco NV Mechelen, Mechelen, Belgium Tibotec NV, Mechelen, Belgium Tibotec NV Mechelen BelgiumTibotec NV, Mechelen, Belgium
Titolo Testata:
SEXUALLY TRANSMITTED INFECTIONS
fascicolo: 6, volume: 77, anno: 2001,
pagine: 449 - 452
SICI:
1368-4973(200112)77:6<449:RAIHIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE; PHENOTYPIC RESISTANCE; MULTIDRUG-RESISTANCE; STAVUDINE; THERAPY; DIDANOSINE; MUTATIONS; PROTEASE;
Keywords:
HIV drug resistance; antiretroviral therapy; HIV diagnostic tests;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Plettenberg, A Gen Hosp St Georg, Infect Dis Outpatient Dept, Haus Z, Lohmuhlenstr 5, D-20099 Hamburg, Germany Gen Hosp St Georg Lohmuhlenstr 5 Hamburg Germany D-20099 y
Citazione:
A. Plettenberg et al., "Resistance analyses in HIV infected patients with a history of multiple antiretroviral treatment regimens", SEX TRANS I, 77(6), 2001, pp. 449-452

Abstract

Objective: To assess HIV-1 isolate based resistance profiles from extensively pretreated patients and effects of a resistance guided switch of antiretroviral therapy. Methods: In a prospective study phenotypic and genotypic resistance analyses were performed on HIV infected individuals with failure of the current therapy and history of at least three antiretroviral regimens. Antiretroviral therapy was changed according to the results. Viral load and CD4 lymphocyte counts were measured at baseline, after 10 (SD 2), and 24 (2) weeks. Results: All patients (n=52) failed their actual regimen. Currently versusever previously taking the specific drug, resistance associated mutations and phenotypic resistance to AZT and 3TC were found in over 80% of individuals; resistance to DDI and D4T was detected in less than 10% of cases. A resistance guided switch of therapy was followed by a median decrease of viral load of 0.5 log10 units after 24 weeks. Individuals resistant to two or more drugs compared with patients with resistance to less than two drugs of ongoing treatment, were switched to a regimen containing DDI, D4T, and a PIor NNRTI. After 10 (SD 2) weeks viral load decrease was pronounced in patients with resistance to at least two drugs in the previous regimen. Conclusions: Among different RTI, the profile of clinically relevant resistance indicates pronounced differences when looking at separate drugs. Regarding virological response, in the context of available drugs, resistance tested with currently used methods is of limited value in extensively pretreated patients and seems to have its value primarily in first or second switch of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:39:25