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Titolo:
Toxicology of environmental estrogens
Autore:
Safe, SH; Pallaroni, L; Yoon, K; Gaido, K; Ross, S; Saville, B; McDonnell, D;
Indirizzi:
Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 rmacol, College Stn, TX 77843 USA Chem Ind Inst Toxicol, Res Triangle Pk, NC 27709 USA Chem Ind Inst Toxicol Res Triangle Pk NC USA 27709 angle Pk, NC 27709 USA Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
REPRODUCTION FERTILITY AND DEVELOPMENT
fascicolo: 4, volume: 13, anno: 2001,
pagine: 307 - 315
SICI:
1031-3613(2001)13:4<307:TOEE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER RISK; MALE REPRODUCTIVE-TRACT; ADIPOSE-TISSUE CONCENTRATIONS; RECEPTOR-ALPHA; BISPHENOL-A; POLYCHLORINATED-BIPHENYLS; ANDROGEN RECEPTOR; MALE-RATS; ORGANOCHLORINE COMPOUNDS; HORMONE-RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Safe, SH Texas A&M Univ, Dept Vet Physiol & Pharmacol, 4466 TAMU, College Stn, TX 77843 USA Texas A&M Univ 4466 TAMU College Stn TX USA 77843 n, TX 77843 USA
Citazione:
S.H. Safe et al., "Toxicology of environmental estrogens", REPROD FERT, 13(4), 2001, pp. 307-315

Abstract

It has been hypothesized that environmental contaminants that modulate endocrine signaling pathways may be causally linked to adverse health effects in humans. There has been particular concern regarding synthetic estrogens and their role in disrupting normal development of the male reproductive tract. Most estrogenic industrial compounds, such as bisphenol A (BPA) and nonylphenol, typically bind estrogen receptors alpha (ER alpha) and beta (ER beta) and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually greater than or equal to 1000-fold lowerthan observed for 17 beta -estradiol (E2). Selective estrogen receptor modulators (SERMs) represent another class of synthetic estrogens that are being developed for treatment of hormone-dependent problems. The SERMs differentially activate wild-type ER alpha and variant forms expressing activationfunction 1 (ER-AF1) and AF2 (ER-AF2) in human HepG2 hepatoma cells transfected with a pC3-luciferase construct, and these in vitro differences reflect their unique in vivo biologies. The HepG2 cell assay has also been used in our laboratories to investigate the estrogenic activities of the following structurally diverse synthetic and phytoestrogens: 4'-hydroxytamoxifen; BPA; 2',4',6'-trichloro-4-biphenylol; 2',3',4',5'-tetrachloro-4-biphenylol; p-t-octylphenol; p-nonylphenol; naringenin; kepone; resveratrol; and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE). The results show that synthetic and phytoestrogens induce distinct patterns of gene activation in HepG2 and U2 osteogenic sarcoma cells, suggesting that these compounds will induce tissue-specific in vivo ER agonist or antagonist activities. The predicted differences between these compounds, based on results of the in vitro bioassay, have been confirmed. For example, BPA inhibits E2-induced responses in the rodent uterus, and HPTE and structurally related compounds are ERa agonists and ERP antagonists in assays carried out in HepG2 and other cancer cell lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:42:07