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Titolo:
The influence of estrogen on the developing male marsupial
Autore:
Renfree, MB; Coveney, D; Shaw, G;
Indirizzi:
Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
REPRODUCTION FERTILITY AND DEVELOPMENT
fascicolo: 4, volume: 13, anno: 2001,
pagine: 231 - 240
SICI:
1031-3613(2001)13:4<231:TIOEOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULLERIAN-INHIBITING SUBSTANCE; DEPENDENT SEX DETERMINATION; OPOSSUM MONODELPHIS-DOMESTICA; WALLABY MACROPUS-EUGENII; SHORT-TAILED OPOSSUM; TESTICULAR DESCENT; TAMMAR WALLABY; POUCH YOUNG; GERM-CELLS; POSTNATAL-DEVELOPMENT;
Keywords:
17 beta-estradiol; gonadal sex reversal; inguinal hernia; persistent Mullerian duct syndrome; tammar wallaby; testicular descent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Renfree, MB Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia UnivMelbourne Melbourne Vic Australia 3010 c 3010, Australia
Citazione:
M.B. Renfree et al., "The influence of estrogen on the developing male marsupial", REPROD FERT, 13(4), 2001, pp. 231-240

Abstract

The genes and hormones involved in gonadal differentiation are highly conserved between eutherians and marsupials, although the timing of the developmental events differs. In marsupials, the testis develops seminiferous cords two days after birth, and the ovaries are not distinguishable until around eight days after birth. Differentiation of the internal genitalia is controlled in marsupials, as in eutherians, by testicular testosterone and Mullerian inhibiting substance, but differentiation of the scrotum in males andmammary primordia in females is hormone-independent. Since the young are easily accessible in the pouch, it is possible to administer gonadal hormones during the period of sexual differentiation. In both Australian and SouthAmerican marsupials, estradiol treatment of neonatal males can induce male-to-female gonadal sex reversal. The testicular transformations range from partial suppression of seminiferous tubule development to the development of a morphologically normal ovary depending on the stage that treatment starts. The sex-reversed testes have a clearly defined cortex and medulla, and there are significantly fewer germ cells. The germ cells are surrounded by follicle-like cells and are in the early stages of meiosis, as is normal for XX germ cells in ovaries. In normal males, germ cells only enter meiosis at the onset of puberty. As in eutherians, estrogen treatment of neonatal male marsupials prevents regression of the Mullerian ducts, which are hypertrophic. Neonatal estradiol exposure also causes hypertrophy of the prostateand urogenital sinus. Estradiol treatment also inhibits transabdominal testicular descent and many animals develop inguinal hernias. The ability of estradiol to cause testis-to-ovary sex reversal in marsupials provides a newway of studying the interactions between genes and hormones in testicular differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:03:51