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Titolo:
Protein coregulators that mediate estrogen receptor function
Autore:
Ratajczak, T;
Indirizzi:
Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia Sir Charles Gairdner Hosp Nedlands WA Australia 6009 , WA 6009, Australia Queen Elizabeth II Med Ctr, Western Australia Inst Med Res, Nedlands, WA 6009, Australia Queen Elizabeth II Med Ctr Nedlands WA Australia 6009 WA 6009, Australia Univ Western Australia, Queen Elizabeth II Med Ctr, Dept Pharmacol, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia
Titolo Testata:
REPRODUCTION FERTILITY AND DEVELOPMENT
fascicolo: 4, volume: 13, anno: 2001,
pagine: 221 - 229
SICI:
1031-3613(2001)13:4<221:PCTMER>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATOR-ACTIVATED RECEPTOR; NUCLEAR HORMONE RECEPTORS; TRANSCRIPTIONAL ACTIVITY; HISTONE DEACETYLASE; CYCLIN D1; N-COR; STEROID-RECEPTORS; BREAST-CANCER; PROMOTER-CONTEXT; LIGAND-BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Ratajczak, T Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Hosp Ave, Nedlands, WA 6009, Australia Sir Charles Gairdner Hosp Hosp Ave Nedlands WA Australia 6009
Citazione:
T. Ratajczak, "Protein coregulators that mediate estrogen receptor function", REPROD FERT, 13(4), 2001, pp. 221-229

Abstract

The recent discovery of estrogen receptor beta as a biological partner with estrogen receptor a in mediating the estrogen response has come at precisely the same time as intensive research is revealing the role played by downstream coregulator proteins in linking nuclear hormone receptor activity to general transcription machinery involved in gene transcriptional activation. In what is a rapidly evolving area of research, findings to date have led to a proposed model of hormonal action, in which a receptor activated byestrogen or cell-membrane-derived phosphorylation-dependent signaling pathways promotes recruitment of selected members of the multifunctional steroid receptor coactivator family and the cointegrators, p300/CBP and P/CAE Theintrinsic histone acetylase activity mediated by these coactivator and cointegrator proteins, alters chromatin structure giving rise to increased transcriptional efficiency. On the other hand, antiestrogen-bound receptors favour the assembly of receptor-co repressor complexes containing the sequence-related corepressors N-CoR (nuclear receptor corepressor) or SMRT (silencing mediator of retinoid and thyroid hormone receptors), localizing histonedeacetylase activity to the promoter and leading to transcriptional repression. The model predicts that a change in the balance between corepressor and coactivator expression in favour of coactivators, might result in antiestrogen resistance. Together with available crystal structure data for estrogen- and antiestrogen-bound receptors, these studies have provided valuableinsights into events that occur subsequent to receptor interaction with specific DNA sequences and have helped define the molecular basis of estrogenand antiestrogen activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:53:12