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Titolo:
Plasma somatostatin and gastrointestinal peptides in Alzheimer's disease and vascular dementia
Autore:
Foy, CJ; Ardill, J; Filmore, D; Lawson, JT; Passmore, AP;
Indirizzi:
Queens Univ Belfast, Dept Geriatr Med, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland Royal Victoria Hosp, Dept Med, Belfast BT12 6BA, Antrim, North Ireland Royal Victoria Hosp Belfast Antrim North Ireland BT12 6BA , North Ireland Belfast City Hosp, Dept Radiol, Belfast BT9 7AD, Antrim, North Ireland Belfast City Hosp Belfast Antrim North Ireland BT9 7AD rim, North Ireland
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 11, volume: 94, anno: 2001,
pagine: 631 - 635
SICI:
1460-2725(200111)94:11<631:PSAGPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENILE DEMENTIA; NEUROPEPTIDES; MANIFESTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Passmore, AP Queens Univ Belfast, Dept Geriatr Med, Whitla Med Bldg,97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Whitla Med Bldg,97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
C.J. Foy et al., "Plasma somatostatin and gastrointestinal peptides in Alzheimer's disease and vascular dementia", QJM-MON J A, 94(11), 2001, pp. 631-635

Abstract

Few markers distinguish between different dementia types. As dementia affects many body systems outside the central nervous system, we investigated gastrointestinal regulatory peptides as possible disease markers in Alzheimer's Disease (AD) and vascular dementia (VaD). Subjects with mild-to-moderate dementia were diagnosed as probable AD and VaD according to defined criteria. Gastrointestinal peptides were stimulated using a standardized meal test, administered after an overnight fast to 58 dementia patients (40 AD, 18VaD) and 47 controls matched for age and sex. Blood samples were taken at designated time intervals, and basal and stimulated plasma concentrations of eleven peptides were determined by radio-immunoassay. Results were analysed using the Kruskal-Wallis one-way analysis of variance; the Mann-Whitney U test was used in post hoc analysis where appropriate. There were significant differences in somatostatin levels but in none of the other peptides. Basal somatostatin was significantly increased in VaD compared to controls (p <0.05), and AD (p <0.005). Maximum stimulated levels were significantly elevated in VaD compared to AD (p <0.01). Median basal and stimulated levelsof somatostatin were increased in VaD compared to AD, but the overlap in individual values between the groups makes it unlikely to be useful in distinguishing the two types of dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:47:13