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Titolo:
EFFICACY AND SAFETY OF PROPHYLACTIC CRANIAL IRRADIATION IN PATIENTS WITH SMALL-CELL LUNG-CANCER
Autore:
VANDEPOL M; TENVELDE GPM; WILMINK JT; VOLOVICS A; TWIJNSTRA A;
Indirizzi:
UNIV HOSP MAASTRICHT,DEPT NEUROL,POB 5800 NL-6202 AZ MAASTRICHT NETHERLANDS UNIV HOSP MAASTRICHT,DEPT PULMONOL NL-6202 AZ MAASTRICHT NETHERLANDS UNIV HOSP MAASTRICHT,DEPT RADIOL NL-6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG,DEPT MED STAT NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
Journal of neuro-oncology
fascicolo: 2, volume: 35, anno: 1997,
pagine: 153 - 160
SICI:
0167-594X(1997)35:2<153:EASOPC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN IRRADIATION; FOLLOW-UP; CARCINOMA; CHEMOTHERAPY; MANAGEMENT;
Keywords:
BRAIN-METASTASIS; SMALL CELL LUNG CANCER; PROPHYLACTIC CRANIAL IRRADIATION; EFFICACY; SIDE-EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M. Vandepol et al., "EFFICACY AND SAFETY OF PROPHYLACTIC CRANIAL IRRADIATION IN PATIENTS WITH SMALL-CELL LUNG-CANCER", Journal of neuro-oncology, 35(2), 1997, pp. 153-160

Abstract

Background: Prophylactic cranial irradiation (PCI) as part of the treament regimen for patients with limited stage small cell lung cancer (SCLC) remains controversial. The present study was performed to analyze the efficacy and safety of PCI in patients with limited stage SCLC who achieved complete remission. Patients and methods: Between 1983 anti 1993, thirty-nine patients with limited stage SCLC who had shown complete remission after chemotherapy were enrolled prospectively into the non-randomized study. Eighteen of them received PCI (PCI+), while 21did not (PCI-). Pretreatment CT or MRI of the brain was performed in all patients. Patients were prospectively evaluated by a neurologist at regular intervals. Results: Three PCI+ patients and seven PCI- patients developed brain metastases. The frequencies of brain metastases were not significantly different between the groups (Fisher's exact test, p = 0.207), but brain metastases in PCI+ patients tended to occur later (log rank, p = 0.008). Overall survival was significantly longer in PCI+ patients (log rank, p < 0.001). Early toxicity consisted of headache, nausea, fatigue, concentration problems and alopecia. These symptoms and signs were mild and usually reversible within a few months. Late toxicity was studied in patients whose survival exceeded two years. Seven PCI+ patients survived for more than two years, while no PCI-patients survived for more than two years. Memory problems were seen in six of the seven patients. These problems were non-disabling and, once established, remained stable for months to years. The most prominent radiologic abnormalities were cortical atrophy and leuko encephalopathy, found in four of the five patients who underwent radiologic follow-up examination. Conclusions: This non-randomized study suggests that PCI may be effective by decreasing the frequency of brain metastasesand by increasing the brain metastasis-free survival and overall survival, with a minor risk of clinical and radiologic neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:19:36