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Titolo:
Adhesion of thrombin-stimulated and unstimulated blood platelets to collagen in the presence of Proteus mirabilis lipopolysaccharides
Autore:
Saluk-Juszczak, J; Wachowicz, B; Zielinski, T; Kaca, W;
Indirizzi:
Univ Lodz, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz PolandPL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz, Inst Microbiol & Immunol, PL-90131 Lodz, Poland Univ Lodz Lodz Poland PL-90131 icrobiol & Immunol, PL-90131 Lodz, Poland Polish Acad Sci, Ctr Microbiol & Virol, Lodz, Poland Polish Acad Sci Lodz Poland ad Sci, Ctr Microbiol & Virol, Lodz, Poland
Titolo Testata:
PLATELETS
fascicolo: 8, volume: 12, anno: 2001,
pagine: 470 - 475
SICI:
0953-7104(200112)12:8<470:AOTAUB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTOXIN; ACTIVATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wachowicz, B Univ Lodz, Dept Gen Biochem, Banacha 12-16, PL-90237 Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 37 Lodz, Poland
Citazione:
J. Saluk-Juszczak et al., "Adhesion of thrombin-stimulated and unstimulated blood platelets to collagen in the presence of Proteus mirabilis lipopolysaccharides", PLATELETS, 12(8), 2001, pp. 470-475

Abstract

Adhesion of blood platelets to collagen may be involved in pathogenesis ofseptic shock after damage of endothelial cells by LPS or inflammatory cytokines. Therefore, analysis of platelet adhesion in the presence of endotoxin seems to be of great importance. We studied in vitro the effects of LPSs (S1959, R110, R45) from Proteus mirabilis (smooth and rough types differingsignificantly in their composition) on the adhesion of unstimulated and thrombin-stimulated platelets to collagen. The adhesion was measured by a static method as absorbance of cell attached proteins. In this work we report that adhesion of resting platelets to collagen was stimulated by all testedLPSs. The effects were dependent on the doses of LPSs. In the presence of LPSs the inhibition of adhesion of thrombin-treated platelets to collagen was observed. The results presented in this paper indicate that LPSs from Proteus mirabilis may act directly on blood platelets and stimulate adhesion of resting platelets to collagen. On the other hand, LPSs can have an inhibitory effect on adhesion of thrombin-stimulated platelets to collagen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:35:35