Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of rat platelet 5-hydroxytryptamine uptake by chlorpyrifos and carbaryl
Autore:
Sachana, M; Flaskos, J; Nikolaidis, E; Hargreaves, A; Alexaki-Tzivanidou, E;
Indirizzi:
Aristotelian Univ Thessaloniki, Fac Med Vet, Dept Biochem & Toxicol, Thessaloniki 54006, Greece Aristotelian Univ Thessaloniki Thessaloniki Greece 54006 i 54006, Greece Aristotelian Univ Thessaloniki, Fac Med Vet, Dept Pharmacol, Thessaloniki 54006, Greece Aristotelian Univ Thessaloniki Thessaloniki Greece 54006 i 54006, Greece Nottingham Trent Univ, Dept Life Sci, Nottingham NG11 8NS, England Nottingham Trent Univ Nottingham England NG11 8NS gham NG11 8NS, England
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 4, volume: 89, anno: 2001,
pagine: 195 - 200
SICI:
0901-9928(200110)89:4<195:IORP5U>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE; BLOOD-PLATELETS; DEVELOPMENTAL NEUROTOXICITY; CELLULAR MECHANISMS; TRANSPORT; SEROTONIN; EXPOSURE; NEURONS; DOPAMINE; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Flaskos, J Aristotelian Univ Thessaloniki, Fac Med Vet, Dept Biochem & Toxicol, Thessaloniki 54006, Greece Aristotelian Univ Thessaloniki Thessaloniki Greece 54006 eece
Citazione:
M. Sachana et al., "Inhibition of rat platelet 5-hydroxytryptamine uptake by chlorpyrifos and carbaryl", PHARM TOX, 89(4), 2001, pp. 195-200

Abstract

The organophosphate insecticide chlorpyrifos and the carbamate insecticidecarbaryl were investigated in adult male rats in terms of their effects onthe activity of brain monoamine oxidase-A (MAO-A) activity and on the platelet uptake of 5-hydroxytryptamine (5-HT). The activities of brain acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE) were also determined. For each compound two different dosage regimens were employed. In the acute study, chlorpyrifos or carbaryl was administered at a single intraperitoneal dose of 100 mg/kg or 50 mg/kg. respectively. In the subacute study, chlorpyrifos was injected at a daily dose of 20 mg/kg for 7 days, whilecarbaryl was given at a daily dose of 10 mg/kg for 14 days. Acute chlorpyrifos administration produced a 85.01% inhibition of AChE and a 43.4% inhibition of BuChE but had no effect on MAO-A activity and 5-HT uptake. In contrast, subacute chlorpyrifos exposure caused a 94.96%, inhibition of AChE anda 85.8% inhibition of BuChE and, also, elicited a significant (35.02%) reduction in the platelet uptake of 5-HT. MAO-A activity was not affected. Acute carbaryl administration produced a 56.38% AChE inhibition and a 55.95% BuChE inhibition and also caused a significant (26.36%) decrease in 5-HT uptake but no change in MAO-A. Subacute carbaryl exposure failed to affect significantly any of the biochemical parameters determined. Interference with the 5-HT system by chlorpyrifos and carbaryl could contribute to the toxicity of these pesticides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:05:49