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Titolo:
Trimeresurus flavoviridis (Habu snake) venom induces human erythrocyte lysis through enzymatic lipolysis, complement activation and decreased membrane expression of CD55 and CD59
Autore:
Yamamoto, C; Tsuru, D; Oda-Ueda, N; Ohno, M; Hattori, S; Kim, ST;
Indirizzi:
Kitakyushu Inst Biophys, Kitakyushu, Fukuoka 8070831, Japan Kitakyushu Inst Biophys Kitakyushu Fukuoka Japan 8070831 a 8070831, Japan Univ Tokyo, Amami Branch, Inst Med Sci, Kagoshima 8941531, Japan Univ Tokyo Kagoshima Japan 8941531 nst Med Sci, Kagoshima 8941531, Japan Sojo Univ, Fac Engn, Kumamoto 8600082, Japan Sojo Univ Kumamoto Japan 8600082 Univ, Fac Engn, Kumamoto 8600082, Japan
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 4, volume: 89, anno: 2001,
pagine: 188 - 194
SICI:
0901-9928(200110)89:4<188:TF(SVI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; HUMAN PLASMA; PROTEIN; PURIFICATION; RECOGNITION; SYSTEM; CELLS; SERUM; ACID; C3A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, C Kitakyushu Inst Biophys, 2-8-21 Norimatsu, Kitakyushu, Fukuoka8070831, Japan Kitakyushu Inst Biophys 2-8-21 Norimatsu Kitakyushu FukuokaJapan 8070831
Citazione:
C. Yamamoto et al., "Trimeresurus flavoviridis (Habu snake) venom induces human erythrocyte lysis through enzymatic lipolysis, complement activation and decreased membrane expression of CD55 and CD59", PHARM TOX, 89(4), 2001, pp. 188-194

Abstract

Trimeresurus flavoviridis (habu snake) bites can be fatal to man because of its virulent venom, which is clinicopathologically classified as haemorrhagic, necrotic, and haemolytic toxins. Trimeresurus flavoviridis venom causes lysis of human erythrocytes in conditions where plasma is present as well as in plasma-free conditions in a dose-dependent manner. The haemolytic process requires Ca2+ and Mg2+ ions in the solution. Additionally, the venominitiates activation of the human complement cascade as evidenced by C3a and C5a releases, complement consumption indicated by CH50 and formation of soluble membrane attack complex, The insertion of membrane attack complex into the erythrocyte membranes is morphologically identified by electronmicroscopy. Immunofluorescence analysis reveals that incubation of erythrocyteswith the venom decreased cell-surface expression of CD55 (decay accelerating factor) and CD59 (protectin), which renders erythrocyte more vulnerable to adherent C3 and C5 convertases and to polymerization of C9 into membranes, and may enhance autologous complement-mediated haemolysis triggered by the venom. Our data demonstrate that Trimeresurus flavoviridis venom induceshaemolysis in the presence of plasma by three distinct mechanisms, direct lipolysis through PLA(2) activity, activation of the human complement system, and cleavages of CD55 and CD59 from erythrocyte membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:25:32