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Titolo:
Protein kinase c isoforms as therapeutic targets in nervous system diseasestates
Autore:
Battaini, F;
Indirizzi:
Univ Roma Tor Vergata, Sch Med, Dept Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 t Neurosci, I-00133 Rome, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 44, anno: 2001,
pagine: 353 - 361
SICI:
1043-6618(200111)44:5<353:PKCIAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; GREEN FLUORESCENT PROTEIN; AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; BRAIN INJURY; SIGNAL-TRANSDUCTION; CALCIUM CHANNELS; ISCHEMIC STROKE; PHORBOL ESTERS; BETA INHIBITOR;
Keywords:
protein kinase C; isozymes; phosphorylation; neuronal pathologies; RACK; activators; inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Battaini, F Univ Roma Tor Vergata, Sch Med, Dept Neurosci, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
F. Battaini, "Protein kinase c isoforms as therapeutic targets in nervous system diseasestates", PHARMAC RES, 44(5), 2001, pp. 353-361

Abstract

Neuronal tissues display high levels of protein kinase C (PKC) activity and isoform expression. The activation of this enzymatic system is important in the control of short and long term brain functions (ion channel regulation, receptor modulation, neurotransmitter release, synaptic potentiation/depression, neuronal survival) that are related to diverse brain pathologies. This review will describe recent developments in PKC regulation and changes in levels, isoforms and activation in acute and chronic neurodegenerativepathologies as well as in affective and psychic disorders. The recent availability of isoform selective inhibitors and activators may help to understand better the relevance of PKC in central nervous system (CNS) physiology and pathology and to identify new and safer pharmacologic strategies to be tested in different disease states. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:13:40