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Titolo:
Cardiovascular effects of fentanyl in conscious rats
Autore:
Baechtold, F; Cavadas, C; Gasser, D; Markert, M; Grouzmann, E; Peterson, KL; Waeber, B; Feihl, F;
Indirizzi:
Univ Hosp, Div Clin Pathophysiol, CH-1011 Lausanne, Switzerland Univ HospLausanne Switzerland CH-1011 ol, CH-1011 Lausanne, Switzerland Univ Hosp, Div Hypertens, CH-1011 Lausanne, Switzerland Univ Hosp Lausanne Switzerland CH-1011 ns, CH-1011 Lausanne, Switzerland Univ Hosp, Clin Chem Lab, CH-1011 Lausanne, Switzerland Univ Hosp Lausanne Switzerland CH-1011 ab, CH-1011 Lausanne, Switzerland Univ Calif San Diego, Div Cardiol, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 1, volume: 443, anno: 2001,
pagine: 155 - 162
SICI:
0031-6768(200110)443:1<155:CEOFIC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; HYPERDYNAMIC SEPSIS; VASCULAR REACTIVITY; ENDOTHELIAL-CELLS; SMOOTH-MUSCLE; SEPTIC RATS; IN-VIVO; INHIBITION; HEART; TOLERANCE;
Keywords:
analgesia; hemodynamics; left ventricular function; opioids; rats; vascular endothelium; vasoconstriction; vasodilatation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Feihl, F Univ Hosp, Div Clin Pathophysiol, CH-1011 Lausanne, Switzerland Univ Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland
Citazione:
F. Baechtold et al., "Cardiovascular effects of fentanyl in conscious rats", PFLUG ARCH, 443(1), 2001, pp. 155-162

Abstract

The polymicrobial sepsis induced by cecal ligation and puncture (CLP) in the rat is widely used in shock research. For ethical reasons, narcotic analgesics are often administered in this model, with the potential risk of confounding effects. In conscious non-septic rats, we investigated the cardiovascular effects of a continuous i.v. infusion of fentanyl (20 mug/kg per h)administered with fluid loading (10 ml/kg per h) for 24 h, a regimen commonly applied in rat CLP. Animals were randomly allocated to receive analgesia with fluid loading (Fentanyl c1roup), or fluid loading alone (Control). All endpoints were assessed after 24 h of infusion. At that time, Control animals had mild respiratory alkalosis, which was essentially abolished by fentanyl. Analgesia mildly elevated the plasma norepinephrine levels [median (interquartile range): Control 232 pg/ml (0-292), Fentanyl 302 pg/ml (234-676), P=0.045] but was devoid of any effect on blood pressure, heart rate, cardiac output (mean +/- SD: Control 388 +/- 61 ml/kg per min, Fentanyl 382 /- 62 mne, per min, P=0.87) and indices of left ventricular function derived from high-fidelity recordings of left ventricular pressure (dP/dt(max): Control 11782 +/- 2324 mmHg/s, Fentanyl 12107 +/- 2816 mmHg/s, P=0.77). In ex vivo experiments carried out immediately after animal sacrifice, no differences were noted between the Control and Fentanyl groups in the sensitivity of endothelium-intact aortic rings to norepinephrine-induced vasoconstriction (-logEC(50): Control 8.78 +/-0.28, Fentanyl 8.83 +/-0.26, P=0.52) or acetylcholine-induced vasodilatation (-logEC(50): Control 7.00 +/-0.37, Fentanyl 7.06 +/-0.26 +/- 0.53, P=0.75). In conclusion, the present data provide no contraindication, and even some support for the ethical use of a highdose i.v. infusion of fentanyl in cardiovascular studies of conscious catheterized rats undergoing CLP or other painful procedures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:51:18