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Titolo:
Association of tobacco smoke exposure and respiratory syncitial virus infection with airways reactivity in early childhood
Autore:
Adler, A; Ngo, L; Tager, IB;
Indirizzi:
Univ Calif Berkeley, Sch Publ Hlth, Div Publ Hlth Biol & Epidemiol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 idemiol, Berkeley, CA 94720 USA Childrens Hosp Oakland, Div Pediat, Oakland, CA 94609 USA Childrens Hosp Oakland Oakland CA USA 94609 Pediat, Oakland, CA 94609 USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 6, volume: 32, anno: 2001,
pagine: 418 - 427
SICI:
8755-6863(200112)32:6<418:AOTSEA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-FUNCTION; MATERNAL SMOKING; BRONCHIAL RESPONSIVENESS; NEWBORN-INFANTS; VIRAL BRONCHIOLITIS; PULMONARY-FUNCTION; PARENTAL SMOKING; TRACT ILLNESS; 1ST YEAR; ASTHMA;
Keywords:
asthma; passive smoking; respiratory tract infection; tobacco smoke; epidemiology; wheezing; bronchial hyperresponsiveness; bronchiolitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Tager, IB Univ Calif Berkeley, Sch Publ Hlth, Div Publ Hlth Biol & Epidemiol, 140 Warren Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 140 Warren Hall Berkeley CA USA 94720 20 USA
Citazione:
A. Adler et al., "Association of tobacco smoke exposure and respiratory syncitial virus infection with airways reactivity in early childhood", PEDIAT PULM, 32(6), 2001, pp. 418-427

Abstract

Exposure to infectious agents and environmental tobacco smoke are thought to induce bronchial hyperresponsiveness (BHR). This study was undertaken todetermine the effects of passive exposure to tobacco smoke and respiratorysyncitial virus (RSV) lower respiratory infection (LRI) during infancy on the occurrence of BHR in the first 2 years of life. Eighty-six cases of documented RSV (mean age, 188 days) and 78 controls (mean age, 162 days) were enrolled from the clinic and in-patient service of a single hospital. None had a history of prior LRI. Subjects were studied at 6-month intervals up to 19 months of age with a standardized respiratory illness and parental smoking questionnaire, partial expiratory flow-volume curves by the "hug" (rapid thoracic compression) technique, and methacholine challenge. Exposure to maternal and paternal cigarette smoking, maternal history of asthma, and mold exposure were associated with decreased levels of length-corrected maximal flow at functional residual capacity (V'(maxFRC)). RSV-LRI was not related to V'(maxFRC). After adjustment Of V-maxFRC for these factors. V'(maxFRC) was a significantly and positively correlated with a methacholine concentration provoking a 40% fall in V'(maxFRC) (PC40) and negatively correlated with dose-response slope. After adjustment for V'(maxFRC), there were no independent effects of tobacco smoke exposure or RSV-LRI on methacholine responses. These data do not support a role for RSV as a risk factor for airways reactivity in childhood and indicate that exposure to tobacco smoke affects airways reactivity through its effects on airways. (C) 2001 Wiley-bss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:00:29