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Titolo:
Frequency-domain analysis of the QRS complex after treatment of childhood cancer with anthracycline cytostatics
Autore:
Mladosievicova, B; Foltinova, A; Luptak, I; Petrasova, H; Hulin, I;
Indirizzi:
Comenius Univ, Sch Med, Inst Pathophysiol, SK-81108 Bratislava, Slovakia Comenius Univ Bratislava Slovakia SK-81108 SK-81108 Bratislava, Slovakia Childrens Univ Hosp, SK-83340 Bratislava, Slovakia Childrens Univ Hosp Bratislava Slovakia SK-83340 40 Bratislava, Slovakia
Titolo Testata:
PEDIATRIC CARDIOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 478 - 482
SICI:
0172-0643(200111/12)22:6<478:FAOTQC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-AVERAGED ELECTROCARDIOGRAM; IDIOPATHIC DILATED CARDIOMYOPATHY; VENTRICULAR LATE POTENTIALS; FOURIER-TRANSFORM ANALYSIS; INDUCED CARDIOTOXICITY; DOXORUBICIN THERAPY; ECG; INFARCTION; CHILDREN;
Keywords:
anthracycline cardiotoxicity; signal-averaged electrocardiography; fast Fourier transform; late effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mladosievicova, B Comenius Univ, Sch Med, Inst Pathophysiol, Sasinkova 4, SK-81108 Bratislava, Slovakia Comenius Univ Sasinkova 4 Bratislava Slovakia SK-81108
Citazione:
B. Mladosievicova et al., "Frequency-domain analysis of the QRS complex after treatment of childhood cancer with anthracycline cytostatics", PEDIAT CARD, 22(6), 2001, pp. 478-482

Abstract

Long-term cardiac complications, occurring several years after completion of anticancer treatment. may develop from subclinical myocardial damage induced during cardiotoxic therapy. The aim of this study was to evaluate the usefulness of frequency-domain signal-averaged ECG analysis of the QRS complex for assessing the cardiotoxicity of anthracycline cytostatics. Altogether, 172 signal-averaged electrocardiography (SAECG) registrations were performed in 50 repeatedly evaluated oncologic patients. These registrations were performed 0.2-15 years after completion of anthracycline therapy for childhood cancer. The control group consisted of 120 healthy children and young volunteers; in 20 of these controls. SAECGs were performed repeatedly. Using gliding window fast Fourier transformation within the QRS complex. values area ratio (AR) 60-120 Hz/ 0-120 Hz were calculated in X. Y, and Z lead. Area ratio of patients after anthracycline therapy was significantly higher than those in control group in X lead. Differences in frequency content in the QRS complex between patients and controls might signal an initial stage of anthracycline-induced myocardial damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:41:57