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Titolo:
Challenges for model-based economic evaluations of postmenopausal osteoporosis interventions
Autore:
Tosteson, ANA; Jonsson, B; Grima, DT; OBrien, BJ; Black, DM; Adachi, JD;
Indirizzi:
Dartmouth Coll Sch Med, Dept Med, Hanover, NH USA Dartmouth Coll Sch Med Hanover NH USA Sch Med, Dept Med, Hanover, NH USA Dartmouth Coll Sch Med, Ctr Evaluat Clin Sci, Dept Community & Family Med,Hanover, NH USA Dartmouth Coll Sch Med Hanover NH USA unity & Family Med,Hanover, NH USA Stockholm Sch Econ, Ctr Hlth Econ, S-11383 Stockholm, Sweden Stockholm SchEcon Stockholm Sweden S-11383 n, S-11383 Stockholm, Sweden Innovus Res Inc, Burlington, ON, Canada Innovus Res Inc Burlington ON Canada vus Res Inc, Burlington, ON, Canada McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada idemiol & Biostat, Hamilton, ON, Canada St Josephs Hosp, Ctr Evaluat Med, Hamilton, ON, Canada St Josephs Hosp Hamilton ON Canada Ctr Evaluat Med, Hamilton, ON, Canada Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA McMaster Univ, St Josephs Hosp, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada hs Hosp, Dept Med, Hamilton, ON, Canada
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 10, volume: 12, anno: 2001,
pagine: 849 - 857
SICI:
0937-941X(2001)12:10<849:CFMEEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; QUALITY-OF-LIFE; HIP FRACTURE; COST-EFFECTIVENESS; WHITE WOMEN; VERTEBRAL FRACTURES; HEALTH OUTCOMES; CLINICAL-TRIAL; PREVENTION; RISK;
Keywords:
cost-effectiveness analysis; decision analysis; osteoporosis; postmenopausal women; quality of life; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Tosteson, ANA Dartmouth Hitchcock Med Ctr, HB 7505,1 Med Ctr Dr, Lebanon, NH 03756 USA Dartmouth Hitchcock Med Ctr HB 7505,1 Med Ctr Dr Lebanon NH USA 03756
Citazione:
A.N.A. Tosteson et al., "Challenges for model-based economic evaluations of postmenopausal osteoporosis interventions", OSTEOPOR IN, 12(10), 2001, pp. 849-857

Abstract

Assessing the cost-effectiveness of long-term treatment for osteoporosis requires use of mathematical models to estimate health effects and costs forcompeting interventions. The primary motivations for model-based analyses include the lack of long-term clinical trial outcome data and the lack of data comparing all relevant treatments within randomized clinical trials. Wereport on specific modeling challenges that arose in the development of a model of the natural history of postmenopausal osteoporosis that is suitable for assessing the cost-effectiveness of osteoporosis interventions among various population subgroups in diverse countries. These include choice of modeling changes in bone mineral density (BMD) or in fracture rate, definition of health states, modeling mortality and costs of long-term care following fracture, incorporation of health utility, and model validation. This report should facilitate future postmenopausal osteoporosis model development and provide insight for decisionmakers who must evaluate model-based economic analyses of postmenopausal osteoporosis interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:33:19