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Titolo:
Defining the genetics of osteoporosis: Using the mouse to understand man
Autore:
Rosen, CJ; Beamer, WG; Donahue, LR;
Indirizzi:
St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, Bangor, ME 04401 USA StJoseph Hosp Bangor ME USA 04401 rosis Res & Educ, Bangor, ME 04401 USA Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 10, volume: 12, anno: 2001,
pagine: 803 - 810
SICI:
0937-941X(2001)12:10<803:DTGOOU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; GROWTH-FACTOR-I; INBRED STRAINS; COMPLEX TRAITS; BONE-DENSITY; MICE; LINKAGE; OSTEOBLASTS; DISSECTION;
Keywords:
congenic; inbred; mice; osteoporosis; QTL; recombinant;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rosen, CJ St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, 360 Broadway,Bangor, ME 04401 USA St Joseph Hosp 360 Broadway Bangor ME USA 04401 or, ME 04401 USA
Citazione:
C.J. Rosen et al., "Defining the genetics of osteoporosis: Using the mouse to understand man", OSTEOPOR IN, 12(10), 2001, pp. 803-810

Abstract

Very low bone mineral density (BMD) is now considered as diagnostic of osteoporosis. Moreover, many women who are osteopenic eventually develop osteoporotic fractures. Hence, bone density testing has occupied center stage inthe diagnosis and treatment of this disorder. In addition, over the last several years, BMD has been utilized as the phenotype of choice for definingheritable markers for osteoporotic fractures. However, genetic studies in humans have been limited to some degree by the tremendous heterogeneity among populations, as well as multiple genetic, heritable and environmental determinants of the BMD phenotype. Recent advances in technology have afforded investigators the opportunity to study acquisition and maintenance of BMDin small animals. Along with newer knockout and transgenic strategies, quantification of mouse bone mass has advanced our understanding of both the biologic and genetic determinants of bone density. In this review, we will examine the use of the mouse to map the heritable factors that regulate boneacquisition. We will also examine the role of newer technology to decompose the bone density phenotype into components that are amenable to genetic studies. This review will focus on three models: (1) healthy inbred (2) recombinant inbred, and (3) congenic strains of mice. Progress in this area with these strains has been rapid, and a summary of several quantitative traitloci (QTLs) is provided. The future of the mouse as a tool to map the genes that define the osteoporosis syndrome is extremely promising.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:05:32