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Titolo:
Ocular Whipple's disease - Earlier definitive diagnosis
Autore:
Chan, RY; Yannuzzi, LA; Foster, CS;
Indirizzi:
Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Immunol & Uveitis Serv,Dept Ophthalmol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114rv,Dept Ophthalmol, Boston, MA 02114 USA
Titolo Testata:
OPHTHALMOLOGY
fascicolo: 12, volume: 108, anno: 2001,
pagine: 2225 - 2231
SICI:
0161-6420(200112)108:12<2225:OWD-ED>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; OCULOFACIAL-SKELETAL MYORHYTHMIA; PROGRESSIVE SUPRANUCLEAR PALSY; TRIMETHOPRIM-SULFAMETHOXAZOLE; OCULOMASTICATORY MYORHYTHMIA; UVEITIS; MANIFESTATIONS; BACILLUS; BRAIN; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Foster, CS Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Immunol & Uveitis Serv,Dept Ophthalmol, 243 Charles St, Boston, MA 02114 USA Harvard Univ 243 Charles St Boston MA USA 02114 n, MA 02114 USA
Citazione:
R.Y. Chan et al., "Ocular Whipple's disease - Earlier definitive diagnosis", OPHTHALMOL, 108(12), 2001, pp. 2225-2231

Abstract

Purpose: Whipple's disease is a rare, chronic, and multiorgan bacterial disease that predominantly involves the gut and its lymphatic drainage in middle-aged Caucasian men but may involve the eye. It is often difficult to diagnose and treat. We report results of one more polymerase chain reaction (PCR) analysis-diagnosed ocular Whipple's disease (OWD) case and the care ofthree new patients with ocular inflammation caused by OWD. Design: Retrospective noncomparative case series. Participants: Three patients. Methods: Diagnostic PCR was performed on a vitreous sample, medical records of three patients with OWD were reviewed, and a literature review (1907 to present) located 74 OWD cases. Analysis of published OWD cases to seek out factors that contribute to earlier, definitive diagnosis and treatment ofOWD is made. Main Outcome Measures: Response of ocular inflammation and vision to treatment. Results: One of 3 new and 4 of 74 published OWD cases reviewed were diagnosed with PCR on vitreous samples and subsequently successfully treated withantibiotics without devastating central nervous system (CNS) sequelae. Conclusion: Diagnostic PCR on vitreous samples and recognition of key presenting symptoms in patients with OWD allows earlier definitive diagnosis, when the disease may be more amenable to antibiotic treatment, compared with"late" CNS Whipple's disease in the cases reviewed. (C) 2001 by the American Academy of Ophthalmology.

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Documento generato il 23/01/20 alle ore 04:00:12