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Titolo:
Interhemispheric asymmetry of regional cerebral blood flow in prepubescentboys with attention deficit hyperactivity disorder
Autore:
Langleben, DD; Austin, G; Krikorian, G; Ridlehuber, HW; Goris, ML; Strauss, HW;
Indirizzi:
Univ Penn, Treatment Res Ctr, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 12, volume: 22, anno: 2001,
pagine: 1333 - 1340
SICI:
0143-3636(200112)22:12<1333:IAORCB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT/HYPERACTIVITY-DISORDER; MAGNETIC-RESONANCE; DEVELOPMENTAL DYSLEXIA; DOPAMINE TRANSPORTER; SUSTAINED ATTENTION; GLUCOSE-METABOLISM; DIRECTED ATTENTION; BRAIN-DEVELOPMENT; FUNCTIONAL MRI; CHILDREN;
Keywords:
ADHD; SPECT; interhemispheric asymmetry; hyperactivity; response inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Langleben, DD Univ Penn, Treatment Res Ctr, Dept Psychiat, 3900 Chestnut St, Philadelphia, PA 19104 USA Univ Penn 3900 Chestnut St Philadelphia PA USA 19104 104 USA
Citazione:
D.D. Langleben et al., "Interhemispheric asymmetry of regional cerebral blood flow in prepubescentboys with attention deficit hyperactivity disorder", NUCL MED C, 22(12), 2001, pp. 1333-1340

Abstract

The prefrontal cortex is asymmetric in both structure and function. In normal subjects, the right prefrontal cortex is activated more than the left during response inhibition. Patients with attention deficit hyperactivity disorder (ADHD) have impaired response inhibition and altered structural interhemispheric asymmetry. This study was conducted to examine the functional interhemispheric asymmetry during response inhibition in children with ADHD. Subjects were divided into three groups according to the level of motor hyperactivity. Blood flow tracer Tc-99m-ethyl cysteinate dimer was injected while subjects were performing a response inhibition task (RIT), followed by single photon emission computerized tomography (SPECT). After three-dimensional reconstruction, filtering and smoothing, individual scans were morphed to a template. Three average group images were created from individual scans. Each average group image was subtracted voxel-by-voxel from its mirror image to compare the regional cerebral blood flow (rCBF) in the right andleft cerebral hemispheres, yielding images of significant interhemisphericrCBF asymmetry. The severe hyperactivity group exhibited most prefrontal left>right rCBF asymmetry and left>right occipitoparietal asymmetry. Reversal of functional prefrontal asymmetry in boys with severe motor hyperactivity supports the hypothesis of right prefrontal cortex dysfunction in ADHD. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:12:56