Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The microtubule associated protein Tau gene and Alzheimer's disease - an association study and meta-analysis
Autore:
Russ, C; Powell, JF; Zhao, JH; Baker, M; Hutton, M; Crawford, F; Mullan, M; Roks, G; Cruts, M; Lovestone, S;
Indirizzi:
Inst Psychiat, Dept Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Neurosci, London SE5 8AF, England Inst Psychiat, Sect Genet Epidemiol & Biostat, London SE5 8AF, England Inst Psychiat London England SE5 8AF & Biostat, London SE5 8AF, England Mayo Clin Jacksonville, Neurogenet Labs, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA Mayo Clin Jacksonville, Dept Neurol, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA Univ S Florida Tampa FLUSA 33613 rida, Roskamp Inst, Tampa, FL 33613 USA Erasmus Sch Ctr, Dept Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Sch Ctr Rotterdam Netherlands NL-3000 DR Rotterdam, Netherlands Univ Antwerp, Flanders Interuniv, Inst Biotechnol, Dept Mol Genet, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 t Mol Genet, B-2020 Antwerp, Belgium Inst Psychiat, Old Age Psychiat Sect, London SE5 8AF, England Inst Psychiat London England SE5 8AF chiat Sect, London SE5 8AF, England
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 314, anno: 2001,
pagine: 92 - 96
SICI:
0304-3940(20011113)314:1-2<92:TMAPTG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; NEUROFIBRILLARY TANGLES; DEMENTIA; POLYMORPHISMS; MUTATION; FTDP-17; POPULATION; HAPLOTYPE; MISSENSE; ISOFORMS;
Keywords:
tau; Alzheimer's disease; polymorphism; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lovestone, S Inst Psychiat, Dept Neurosci, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF England
Citazione:
C. Russ et al., "The microtubule associated protein Tau gene and Alzheimer's disease - an association study and meta-analysis", NEUROSCI L, 314(1-2), 2001, pp. 92-96

Abstract

Several studies have suggested an association between polymorphisms and anextended haplotype of the microtubule associated protein tau gene and Alzheimer's disease (AD) in synergy with apolipoprotein E (APOE) epsilon4 status. However these findings have not been consistently replicated. We investigated the role of the tau haplotype in AD by conducting an association study as well as a meta-analysis of all the studies conducted to date. We examined six polymorphisms known to be in the extended tau haplotypes, one in exon 7 and five in and around exon 9 in 200 late onset AD and 189 control samples. All the polymorphisms examined fell into the recognised tau haplotypes. There was no statistical significant association with any of the polymorphisms and late onset AD. Stratification of data by APOE epsilon4 status also produced no strongly significant association. The meta-analysis showed no significant differences between AD cases and controls, however stratification of data by APOE epsilon4 status showed a small significant decrease inthe H1 haplotype in AD before correction for multiple testing. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:17:33