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Titolo:
Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus
Autore:
Kim, HJ; Moon, KD; Oh, SY; Kim, SP; Lee, SR;
Indirizzi:
Keimyung Univ, Sch Med, Dept Pharmacol, Taegu 700712, South Korea KeimyungUniv Taegu South Korea 700712 rmacol, Taegu 700712, South Korea Keimyung Univ, Sch Med, Brain Res Inst, Taegu 700712, South Korea KeimyungUniv Taegu South Korea 700712 s Inst, Taegu 700712, South Korea Kyungpook Natl Univ, Dept Food Sci & Technol, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea Sangju Natl Univ, Dept Food Engn, Sangju 742170, South Korea Sangju Natl Univ Sangju South Korea 742170 n, Sangju 742170, South Korea Keimyung Univ, Sch Med, Dept Pathol, Taegu 700712, South Korea Keimyung Univ Taegu South Korea 700712 Pathol, Taegu 700712, South Korea
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 314, anno: 2001,
pagine: 65 - 68
SICI:
0304-3940(20011113)314:1-2<65:EFOMEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINATE-INDUCED NEUROTOXICITY; RAT HIPPOCAMPUS; GLUTAMATE; APOPTOSIS; BRAIN; ANTIOXIDANT; RECEPTORS; ISCHEMIA; BINDING; BL.;
Keywords:
Gastrodia elate; kainic acid; excitotoxicity; seizure; hippocampus; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SR Keimyung Univ, Sch Med, Dept Pharmacol, 194 Dongsan Dong, Taegu 700712, South Korea Keimyung Univ 194 Dongsan Dong Taegu South Korea 700712 uth Korea
Citazione:
H.J. Kim et al., "Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus", NEUROSCI L, 314(1-2), 2001, pp. 65-68

Abstract

Gastrodia elata (GE) has been used traditionally for the treatment of convulsive diseases such as epilepsy in oriental countries including South Korea and still occupies an important place in traditional medicine in Asia. Westudied the anticonvulsive effect and protective effect of the ether fraction of methanol extracts (EFME) of GE against hippocampal neuronal damage after kainic acid administration in mice. Mice were treated with the EFME ofGE (200 or 500 mg/kg per day, p.o.) for 14 days before kainic acid injection (45 mg/kg, i.p.). The EFME of GE (at the dose of 500 mg/kg) delayed the onset time of neurobehavioral change (P < 0.01) and reduced the severity ofconvulsions (P < 0.05) and hippocampal neuronal damage in the CA1 (P < 0.01) and CA3 (P < 0.05) regions. Our results show that The EFME of GE has anticonvulsive effect and putative neuroprotective effect against excitotoxicity induced by kainic acid. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:04:25