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Titolo:
Sequential up-regulation of the c-fos, c-jun and bax genes in the cortex, striatum and cerebellum induced by a single injection of a low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice
Autore:
Chen, JYR; Hsu, PC; Hsu, IL; Yeh, GC;
Indirizzi:
Taipei Med Univ, Dept Pediat, Taipei 110, Taiwan Taipei Med Univ Taipei Taiwan 110 Univ, Dept Pediat, Taipei 110, Taiwan Taipei Med Univ, Sch Med, Dept Pediat, Taipei 110, Taiwan Taipei Med UnivTaipei Taiwan 110 h Med, Dept Pediat, Taipei 110, Taiwan Taipei Med Univ, Grad Inst Med Sci, Taipei 110, Taiwan Taipei Med Univ Taipei Taiwan 110 Grad Inst Med Sci, Taipei 110, Taiwan Taipei Med Univ, Grad Inst Cell & Mol Biol, Taipei 110, Taiwan Taipei Med Univ Taipei Taiwan 110 st Cell & Mol Biol, Taipei 110, Taiwan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 314, anno: 2001,
pagine: 49 - 52
SICI:
0304-3940(20011113)314:1-2<49:SUOTCC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS IN-VIVO; SUBSTANTIA-NIGRA; DOPAMINERGIC-NEURONS; PARKINSONISM; APOPTOSIS; EXPRESSION; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; NEUROTOXICITY; COMPACTA;
Keywords:
MPTP; mouse brain; apoptosis; c-fos; c-jun; bax; reverse transcription-polymerase chain reaction; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Yeh, GC Taipei Med Univ, Dept Pediat, Taipei 110, Taiwan Taipei Med Univ Taipei Taiwan 110 ept Pediat, Taipei 110, Taiwan
Citazione:
J.Y.R. Chen et al., "Sequential up-regulation of the c-fos, c-jun and bax genes in the cortex, striatum and cerebellum induced by a single injection of a low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice", NEUROSCI L, 314(1-2), 2001, pp. 49-52

Abstract

We investigated whether single injection of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) (20 mg/kg) will alter the expression of pro-apoptotic genes, namely, the c-fos, c-jun, and bax, in the striatum, cortex, and cerebellum of adult male C57BL/6 mice using reverse transcription-polymerase chain reaction assay. Injection of MPTP induced a transient decrease in thecontent of tyrosine hydroxylase estimated by the immunoreactivity in the striatum, which completely recovered 14 day after injection. A rapid but transient up-regulation of c-fos and c-jun genes occurred an hour after MPTP-injection, and a delayed but persistent up-regulation of bax gene expressionoccurred 3 day after injection. The up-regulation of these genes was present in all the examined brain regions. This result suggests that MPTP, at a low dose causing transient degeneration in the striatum, is capable of triggering two genetic pathways related to the generation of apoptosis in both dopaminergic and non-dopaminergic systems in the mouse brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 17/09/19 alle ore 22:41:57