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Titolo:
Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway
Autore:
Kapur, A; Yeckel, M; Johnston, D;
Indirizzi:
Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Div Neurosci, Houston, TX 77030 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 107, anno: 2001,
pagine: 59 - 69
SICI:
0306-4522(2001)107:1<59:HMFAEC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT HIPPOCAMPUS; CALCIUM TRANSIENTS; DENDRITIC SPINES; GUINEA-PIG; CHANNELS; SYNAPSES; LOCALIZATION; STIMULATION; ACTIVATION;
Keywords:
hippocampus; inositol 1,4,5-trisphosphate receptors; Ca2+ imaging; Ca2+ waves; synaptic plasticity; stratum lucidum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Johnston, D Baylor Coll Med, Div Neurosci, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
A. Kapur et al., "Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway", NEUROSCIENC, 107(1), 2001, pp. 59-69

Abstract

Mossy fiber activity can evoke Ca2+ release from internal stores in CA3 neurons, but the physiological conditions under which this occurs and the mechanisms underlying the release are not understood. Using rat hippocampal slices we report here that short trains of mossy fiber stimulation activate group I metabotropic glutamate receptors (mGluRs) on CA3 pyramidal neurons and elicit waves of Ca2+ release from inositol 1,4,5-trisphosphate (IP3) sensitive internal stores that propagate from stratum lucidum to the soma and in some cases distally out the dendrites. Activation of mGluR1,5 receptors by an agonist trans-azetidine-2,4-dicarboxylic acid (tADA) applied to stratum lucidum was also sufficient to induce waves of Ca2+ release. This release was blocked by internal heparin, but not by dantrolene, suggesting the involvement Of IP3 rather than ryanodine receptors in not only the initial release but also in the maintenance of the propagating waves. Release could be facilitated by Ca2+ influx through voltage-gated Ca2+ channels, which is consistent with the known Ca2+ sensitivity of IP3 receptors,These results provide insight into the mechanisms and conditions of Ca2+ release in CA3 neurons and demonstrate the powerful influence mossy fiber input can have on these neurons. (C) 2001 IBRO, Published by Elsevier ScienceLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:27:30