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Titolo:
Depletion of substance P from rat primary sensory neurons by ATP, an implication of P2X receptor-mediated release of substance P
Autore:
Nakatsuka, T; Mena, N; Ling, J; Gu, JG;
Indirizzi:
Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA Univ FloridaGainesville FL USA 32610 ain Inst, Gainesville, FL 32610 USA Univ Florida, Dept Oral Surg, Div Neurosci, Gainesville, FL 32610 USA UnivFlorida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 107, anno: 2001,
pagine: 293 - 300
SICI:
0306-4522(2001)107:2<293:DOSPFR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROOT GANGLION NEURONS; DORSAL HORN NEURONS; GATED ION CHANNELS; SPINAL-CORD; GUINEA-PIG; IMMUNOCYTOCHEMICAL LOCALIZATION; NMDA RECEPTORS; ACTIVATION; IMMUNOREACTIVITY; INTERNALIZATION;
Keywords:
ATP P2X receptors; substance P; dorsal root ganglion; dorsal horn; inflammation; nociception;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gu, JG Univ Florida, McKnight Brain Inst, Box 100416, Gainesville, FL 32610 USA Univ Florida Box 100416 Gainesville FL USA 32610 ille, FL 32610 USA
Citazione:
T. Nakatsuka et al., "Depletion of substance P from rat primary sensory neurons by ATP, an implication of P2X receptor-mediated release of substance P", NEUROSCIENC, 107(2), 2001, pp. 293-300

Abstract

Effects of ATP on substance P immunoreactivity were examined in cultured dorsal root ganglion neurons. We found that treatment or dorsal root ganglion neurons with ATP significantly depleted substance P immunoreactivity on the neurites and somata of the neurons, The effects of ATP were significantly inhibited by the purinergic P2 receptor antagonists suramin (30 muM) and pyridoxal-phosphate-6-azophenyl-2 ' ,4 ' -disulfonic acid (10 muM). We alsoshowed that ATP-induced depletion of substance P immunoreactivity from dorsal root ganglion neurons depended on the entry of Ca2+. In a spinal cord slice preparation. we also found the internalization of neurokinin-1/substance P receptors in many dorsal horn neurons following the application of ATPor alpha,beta -methylene-ATP,Together these results indicate that activation of P2X receptors may result in release of substance P from primary afferent neurons. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:44:32