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Titolo:
Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex
Autore:
Manns, ID; Mainville, L; Jones, BE;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 107, anno: 2001,
pagine: 249 - 263
SICI:
0306-4522(2001)107:2<249:EFGIAT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
AREA 35 CORTICES; LONG-TERM POTENTIATION; RAT CEREBRAL-CORTEX; CHOLINE-ACETYLTRANSFERASE; HIPPOCAMPAL-FORMATION; ACID DECARBOXYLASE; NUCLEUS BASALIS; RHESUS-MONKEY; INHIBITORY INTERNEURONS; EFFERENT CONNECTIONS;
Keywords:
choline acetyltransferase; glutamic acid decarboxylase; phosphate-activated glutaminase; hippocampal region; cholera toxin; retrograde transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, BE McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQCanada H3A 2B4 2B4, Canada
Citazione:
I.D. Manns et al., "Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex", NEUROSCIENC, 107(2), 2001, pp. 249-263

Abstract

Basal forebrain neurons play important parts in processes of cortical activation and memory that have been attributed to the cortically projecting: cholinergic neurons. Yet, non-cholinergic neurons also project to the cerebral cortex and also appear to participate in processes of cortical modulation and plasticity. GABAergic neurons compose a portion of the cortically projecting cell group, but do not fully account for the non-cholinergic cell contingent. In the present study in the rat. we investigated whether the non-cholinergic, non-GABAergic cell component might be composed of glutamatergic neurons. We examined afferents to the entorhinal cortex. which is known to be modulated by basal forebrain neurons and to be critically involved inmemory. Dual immunofluorescent staining was performed for cholera toxin, as retrograde tracer, and phosphate-activated glutaminase, the synthetic enzyme for the neurotransmitter pool of glutamate. The retrogradely labeled cells were distributed across the basal forebrain through the medial septum, diagonal band, magnocellular preoptic area and substantia innominata. The major proportion ( similar to 80%) of the retrogradely labeled cells was found to be immunopositive for phosphate-activated glutaminase. Equal minor proportions (similar to 40%) were immunopositive for choline acety[transferase and glutamic acid decarboxylase. In other material dual-immunostained forneurotransmitter enzymes. similar to 95%, of choline acetyltransferase- and similar to 60% of glutamic acid decarboxylase-immunopositive neurons werealso immunopositive for phosphate-activated glutaminase. From these results it appears that a significant proportion of these cell groups, including their cortically projecting contingents, could synthesizeglutamate together with acetylcholine or GABA as neurotransmitters and another proportion of cells could synthesize glutamate alone. Accordingly, as either co-transmitter or primary transmitter within basalocortical afferents. glutamate could have the capacity to modulate the entorhinal cortex and promote its role in memory. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:58:31