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Titolo:
Acidic fibroblast growths factor (FGF-I) in the anterior horn cells of ALSand control cases
Autore:
Kage, M; Yang, Q; Sato, H; Matsumoto, S; Kaji, R; Akiguchi, I; Kimura, H; Tooyama, I;
Indirizzi:
Shiga Univ Med Sci, Neurosci Res Ctr, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 r, Otsu, Shiga 5202192, Japan Kyoto Univ, Dept Neurol, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Dept Neurol, Kyoto, Japan Otowa Hosp, Dept Pathol, Kyoto, Japan Otowa Hosp Kyoto JapanOtowa Hosp, Dept Pathol, Kyoto, Japan Kitano Hosp, Dept Neurol, Osaka, Japan Kitano Hosp Osaka JapanKitano Hosp, Dept Neurol, Osaka, Japan Univ Tokushima, Dept Clin Neurosci, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 t Clin Neurosci, Tokushima 770, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3799 - 3803
SICI:
0959-4965(200112)12:17<3799:AFGF(I>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR PREVENTS DEATH; FACTOR MESSENGER-RNA; SPINAL-CORD; CHOLINERGIC NEURONS; BASAL FOREBRAIN; FACIAL-NERVE; EXPRESSION; INJURY; MICE;
Keywords:
amyotrophic lateral sclerosis (ALS); choline acetyltransferase; FGF; motoneuron; RT-PCR; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tooyama, I Shiga Univ Med Sci, Neurosci Res Ctr, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 iga 5202192, Japan
Citazione:
M. Kage et al., "Acidic fibroblast growths factor (FGF-I) in the anterior horn cells of ALSand control cases", NEUROREPORT, 12(17), 2001, pp. 3799-3803

Abstract

The expression and localization of acidic fibroblast growth factor (aFGF-,FGF-I) were examined in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) and controls by reverse transcription-polymerase chain reaction (RT-PCR) method and immunohistochemistry. The RT-PCR experiments demonstrated that aFGF amplification products were clearly detected in all control cases but could be scarcely seen in ALS patients. aFGF immunoreactivity was detected in the anterior horn cells of the spinal cord. Double immunostaining for aFGF and choline acetyltransferase revealed that the majority(95.9%) of cholinergic neurons expressed aFGF. In ALS cases, the number and the staining intensity of aFGF-positive neurons were markedly decreased. These results suggest that aFGF is involved in AILS pathology. NeuroReport 12:3799-3803 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:35:12