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Titolo:
The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats
Autore:
Ruggeri, P; Molinari, C; Brunori, A; Cogo, CE; Mary, DASG; Picchio, V; Vacca, G;
Indirizzi:
Univ Genoa, Dept Expt Med, Sect Human Physiol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 Sect Human Physiol, I-16132 Genoa, Italy Univ Piemonte Orientale A Avogadro, Dept Med Sci, I-28100 Novara, Italy Univ Piemonte Orientale A Avogadro Novara Italy I-28100 00 Novara, Italy Univ Leeds, Inst Cardiovasc Res, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3719 - 3722
SICI:
0959-4965(200112)12:17<3719:TDEOIO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM; SENSITIVITY; MECHANISMS; GLUCOSE; LOCALIZATION; RECEPTORS; NERVE;
Keywords:
autonomic nervous system; brain stem; cardiovascular control; insulin; nucleus tractus solitarii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ruggeri, P Univ Genoa, Dept Expt Med, Sect Human Physiol, Viale Benedetto XV 3, I-16132 Genoa, Italy Univ Genoa Viale Benedetto XV 3 Genoa Italy I-16132 noa, Italy
Citazione:
P. Ruggeri et al., "The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats", NEUROREPORT, 12(17), 2001, pp. 3719-3722

Abstract

The present investigation was designed to determine the direct effect of insulin on the spontaneous discharge of barosensitive neurones in the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane. Microinjection of 20 nl insulin (101U/ml) into NTS decreased the spontaneous discharge of 38 of the 52 units studied (73.1%), and this decrease was augmented by increasing the concentration to 401U/ml. Microinjections of insulin vehicle,glucose, hydralazine or phenylephrine did not elicit significant changes in the spontaneous discharge of NTS barosensitive neurones. These results demonstrate that insulin inhibits the spontaneous discharge of barosensitive NTS neurones. They suggest that insulin increases sympathetic nervous activity via a central neural mechanism and may play a role in the modulation ofcardiovascular information within the NTS. NeuroReport 12:3719-3722 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 04/04/20 alle ore 01:37:38