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Titolo:
Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease
Autore:
Datla, KP; Christidou, M; Widmer, WW; Rooprai, HK; Dexter, DT;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Neuroinflammat,London W6 8RF, England Univ London Imperial Coll Sci Technol & Med LondonEngland W6 8RF ngland Inst Psychiat, Dept Neuropathol, Expt Neurooncol Grp, London SE5 8AF, England Inst Psychiat London England SE5 8AF ooncol Grp, London SE5 8AF, England State Florida, Dept Neuropathol, Lake Alfred, FL USA State Florida Lake Alfred FL USA , Dept Neuropathol, Lake Alfred, FL USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3871 - 3875
SICI:
0959-4965(200112)12:17<3871:TDANEO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGRAL IRON CONTENT; SUBSTANTIA-NIGRA; ANTIOXIDANT ACTIVITIES; SELECTIVE INCREASE; DNA-DAMAGE; CELL-DEATH; BRAIN; GLUTATHIONE; MECHANISMS;
Keywords:
antioxidant; flavonoid; neuroprotection; 6-OHDA lesion; Parkinson's disease; tangeretin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dexter, DT Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Neuroinflammat,Charing Cross Campus,Fulham Palace Rd, London W6 8RF, England Univ London Imperial Coll Sci Technol & Med Charing Cross Campus,Fulham Palace Rd London England W6 8RF
Citazione:
K.P. Datla et al., "Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease", NEUROREPORT, 12(17), 2001, pp. 3871-3875

Abstract

Neuroprotective effects of a natural antioxidant tangeretin, a citrus flavonoid, were elucidated in the 6-hydroxydopamine (6-OHDA) lesion rat model of Parkinson's disease (PD), after bioavailability studies. Following the chronic oral administration (10 mg/kg/day for 28 days), significant levels oftangeretin were detected in the hypothalamus, striatum and hippocampus (3.88, 2.36 and 2.00 ng/mg, respectively). The levels in the liver and plasma were 0.59 ng/mg and 0.11 ng/ml respectively. Unilateral infusion of the dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA; 8 mug), onto medial forebrain bundle significantly reduced the number of tyrosine hydroxylase positive (TH+) cells in the substantia nigra and decreased striatal dopamine content in the vehicle treated rats. Sub-chronic treatment of the rats with highdoses of tangeretin (20 mg/kg/day for 4 days; p.o.) before 6-OHDA lesioning markedly reduced the loss of both TH+ cells and striatal dopamine content. These studies, for the first time, give evidence that tangeretin crosses the blood-brain barrier. The significant protection of striato-nigral integrity and functionality by tangeretin suggests its potential use as a neuroprotective agent. NeuroReport 12:3871-3875 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:27:33