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Titolo:
Adenosine A(2A), 5-HT1A, and 5-HT7 receptor in neonatally pregnenolone-treated rats
Autore:
Shirayama, Y; Muneoka, KT; Takigawa, M; Minabe, Y;
Indirizzi:
Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Div Cort Funct Disorder, Kodaira, Tokyo, Japan Natl Inst Neurosci Kodaira Tokyo Japan t Disorder, Kodaira, Tokyo, Japan Kagoshima Univ, Fac Med, Dept Neuropsychiat, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 sychiat, Kagoshima 8908520, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3773 - 3776
SICI:
0959-4965(200112)12:17<3773:AA5A5R>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D-2; STRIATUM; A(1); AGONISTS; BINDING; SCHIZOPHRENIA; HALOPERIDOL; RESPONSES; INCREASE; SYSTEM;
Keywords:
adenosine A(2A) receptor; 5-HT1A receptor; 5-HT7 receptor; neonatal; neurosteroids; pregnenolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shirayama, Y Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Lab Mol Psychiat,Dept Psychiat, 34 Park St, New Haven, CT 06508 USA Yale Univ 34 Park St New Haven CT USA 06508 ven, CT 06508 USA
Citazione:
Y. Shirayama et al., "Adenosine A(2A), 5-HT1A, and 5-HT7 receptor in neonatally pregnenolone-treated rats", NEUROREPORT, 12(17), 2001, pp. 3773-3776

Abstract

Steroid hormones synthesized in the brain, called 'neurosteroids', modulate neuronal activity. We treated, neonatal rats with a main precursor of theneurosteroidogenesis, pregnenolone, and examined adenosine A(2A) receptor,5-hydroxytryptamine (5-HT)(1A) and 5-HT7 receptor densities in the front-parietal cortex in juvenile and adult rats. In receptor binding assay using [H-3]CGS21680 and [H-3]8-OH-DPAT, it was shown that neonatal pregnenolone-treatment induced a significant decrease in the adenosine A2A receptor density with no significant effects on the 5-HT1A and 5-HT7 receptor densities. NeuroReport 12:3773-3776 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:50:52