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Titolo:
Decreased pallidal GABA following reverse microdialysis with, clozapine, but not haloperidol
Autore:
See, RE; Berglind, WJ;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3655 - 3658
SICI:
0959-4965(200112)12:17<3655:DPGFRM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; GLOBUS-PALLIDUS; ANTIPSYCHOTIC-DRUGS; EXTRACELLULAR DOPAMINE; VENTRAL PALLIDUM; FOS EXPRESSION; RATS; RECEPTORS; NEURONS; GLUTAMATE;
Keywords:
antipsychotic; basal ganglia; clozapine; GABA; globus pallidus; haloperidol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: See, RE Med Univ S Carolina, Dept Physiol & Neurosci, 173 Ashley Ave, Charleston, SC 29425 USA Med Univ S Carolina 173 Ashley Ave Charleston SC USA 29425 425 USA
Citazione:
R.E. See e W.J. Berglind, "Decreased pallidal GABA following reverse microdialysis with, clozapine, but not haloperidol", NEUROREPORT, 12(17), 2001, pp. 3655-3658

Abstract

Changes in striatopallidal GABA are believed to play a significant role inthe motor side effects produced by antipsychotic drugs (APDs). In the current study, we measured extracellular GABA in the globus pallidus (GP) of rats. GABA release was partially impulse- and Ca2+-dependent, as evidenced bydecreased efflux following tetrodotoxin (TTX) or removal of Ca2+. In addition, GABA release was significantly increased by high K+ (100 mM KCl) stimulation. Reverse dialysis of the atypical APD, clozapine (1-100 muM), produced a concentration dependent decrease in extracellular GABA. In contrast, the typical APD, haloperidol (1-100 muM), had no significant effect on GABA levels. These results suggest that clozapine has direct actions within the GP, while the effects of haloperidol are most likely mediated through its effects in the striatum. The clozapine-induced decrease in pallidal GABA mayaccount for its low motor side effect liability. NeuroReport 12:3655-3658 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 23/01/20 alle ore 03:40:33