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Titolo:
The T-cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERKpathway
Autore:
Chuenkova, MV; Pereira, MA;
Indirizzi:
Tufts Univ, Sch Med, Dept Pathol, Parasitol Res Ctr, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 l, Parasitol Res Ctr, Boston, MA 02111 USA
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3715 - 3718
SICI:
0959-4965(200112)12:17<3715:TTTIPC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; EXPERIMENTAL CHAGAS-DISEASE; ACTIVATED PROTEIN-KINASE; NEUROTROPHIC FACTOR;
Keywords:
ERK; MAPK; neuronal differentiation; neuronal survival; PC12; trans-sialidase; Trypanosoma cruzi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira, MA Tufts Univ, Sch Med, Dept Pathol, Parasitol Res Ctr, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 , MA 02111 USA
Citazione:
M.V. Chuenkova e M.A. Pereira, "The T-cruzi trans-sialidase induces PC12 cell differentiation via MAPK/ERKpathway", NEUROREPORT, 12(17), 2001, pp. 3715-3718

Abstract

The trans-sialidase (TS) of Tryponosoma cruzi induces survival and differentiation of neuronal and glial cells. This mechanism underlying survival isvia phosphatidylinositol 3-kinase (PI3K) but how TS promotes neuronal differentiation remained to be determined. Here we show that TS-induced neuriteoutgrowth in PC12 cells is through sustained activation of the mitogen-activated protein kinase or ERK cascade and, therefore, by a signaling mechanism distinct from the one it uses to induce cell survival. Such differentialactivation of signal pathways in neuronal cells to effectuate diverse biological activities is analogous to the action of authentic neurotrophins andother growth factors, thereby reinforcing the novel concept of T. cruzi mimicry of host neurotrophic factor(s). NeuroReport 12:3715-3718 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 07/04/20 alle ore 22:17:48