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Titolo:
Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia
Autore:
Miwa, H; Fuwa, T; Nishi, K; Kondo, T;
Indirizzi:
Tokyo Metropolitan Inst Neurosci, Dept Neurol, Tokyo 1838562, Japan Tokyo Metropolitan Inst Neurosci Tokyo Japan 1838562 okyo 1838562, Japan Wakayama Med Univ, Wakayama 6418510, Japan Wakayama Med Univ Wakayama Japan 6418510 d Univ, Wakayama 6418510, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 17, volume: 12, anno: 2001,
pagine: 3795 - 3798
SICI:
0959-4965(200112)12:17<3795:SAAFSI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOBUS-PALLIDUS; C-FOS; PALLIDOSTRIATAL PROJECTION; EXPRESSION; NUCLEUS; NEURONS; RAT; LESIONS; HALOPERIDOL; ANTAGONISTS;
Keywords:
c-fos; globus pallidus; haloperidol; striatum; subthalamic nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Miwa, H Tokyo Metropolitan Inst Neurosci, Dept Neurol, 2-6 Musashidai, Tokyo 1838562, Japan Tokyo Metropolitan Inst Neurosci 2-6 Musashidai Tokyo Japan 1838562
Citazione:
H. Miwa et al., "Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia", NEUROREPORT, 12(17), 2001, pp. 3795-3798

Abstract

Systemic administration of a dopamine D2 receptor blocker, haloperidol, but not vehicle, significantly increased the number of c-Fos-immunoreactive neurons in the globus pallidus (GP) in rats. Dual immunohistochemistry, a combination of c-Fos immunohistochemistry and retrograde tracing experiments with cholera toxin B (ChB), revealed that a subset, of the c-Fos-immunoreactive GP neurons was pallidostriatal feedback neurons. Lesioning of the subthalamic nucleus (STN) by local infection of ibotenic acid inhibited the haloperidol-induced c-Fos expression in the GP neurons, suggesting that the activation of GP neurons is a result of increased excitatory drives from the STN. Therefore, the present findings are evidence of the existence of the subthalamo-pallido-striatal axis as a feedback system in the internal circuits of the basal ganglia. NeuroReport 12:3795-3798 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:28:44