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Titolo:
Changes in vesicular monoamine transporter (VMAT2) and synaptophysin in rat substantia nigra and prefrontal cortex induced by psychotropic drugs
Autore:
Zucker, M; Weizman, A; Harel, D; Rehavi, M;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel Beilinson Med Ctr, Geha Psychiat Hosp, IL-49100 Petah Tiqwa, Israel Beilinson Med Ctr Petah Tiqwa Israel IL-49100 -49100 Petah Tiqwa, Israel Felsenstein Med Res Ctr, Petah Tiqwa, Israel Felsenstein Med Res Ctr Petah Tiqwa Israel Res Ctr, Petah Tiqwa, Israel
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 44, anno: 2001,
pagine: 187 - 191
SICI:
0302-282X(2001)44:4<187:CIVMT(>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE TRANSPORTER; STRIATAL DOPAMINE; HALOPERIDOL; INHIBITORS; EXPRESSION; SECRETION; VESICLES; DENSITY; CELLS;
Keywords:
vesicular monoamine transporter; VMAT2; synaptophysin; L-dopa; phenelzine; lithium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Rehavi, M Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 -69978 Tel Aviv, Israel
Citazione:
M. Zucker et al., "Changes in vesicular monoamine transporter (VMAT2) and synaptophysin in rat substantia nigra and prefrontal cortex induced by psychotropic drugs", NEUROPSYCHB, 44(4), 2001, pp. 187-191

Abstract

We investigated the regulatory effect of the dopaminergic agent L-dopa, the mood stabilizer lithium and the nonselective monoamine oxidase inhibitor phenelzine on brain vesicular monoamine transporter (VMAT2) expression. Rats were treated chronically (21 days) with the three psychoactive drugs. VMAT2 gene expression at the protein level was assessed in the prefrontal cortex and striatum by autoradiography with high-affinity [H-3]dihydrotetrabenazine ([H-3]TBZOH) binding and at the mRNA level in the substantia nigra pars compacta by in situ hybridization. In addition, the effect of various treatments on the synaptophysin mRNA level was determined in the substantia nigra by in situ hybridization. Chronic administration of L-dopa resulted in a significant decrease (28%, p < 0.05) in the density of [H-3]TBZOH bindingin the prefrontal cortex but had no effect on VMAT2 and synaptophysin mRNAlevels in the substantia nigra. Lithium treatment increased [H-3]TBZOH-specific binding in the prefrontal cortex (23%, p < 0.05) but had no effect onVMAT2 and synaptophysin mRNA levels. Phenelzine did not modulate VMAT2 gene expression but reduced the synaptophysin mRNA level (19%, p < 0.05). The modulatory activities of these drugs, although relatively weak, may be relevant to the drug-induced synaptic and neuronal plasticity as well as to themolecular and cellular pathophysiology of monoamine-related neuropsychiatric disorders. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:01:52