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Titolo:
A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPELT in parkinsonism
Autore:
Marek, K; Seibyl, J; Holloway, R; Kieburtz, K; Oakes, D; Lang, A; Yim, J; Dey, H; Cellar, J; Fussell, B; Broshjeit, S; Early, M; Smith, EO; Sudarsky, L; Johnson, KA; Corwin, C; Johnson, D; Lajoie, S; Reich, SG; Frost, JJ; Goldberg, P; Flesher, JE; Feigin, A; Mazurkiewicz, J; Castronuovo, J; Joseph, F; Cove, G; DiRocco, A; Olanow, CW; Machac, J; Cotei, D; Webner, P; Rudolph, A; Day, D; Casaceli, C; Freimuth, A; Orme, C; Hodgeman, K; Eberly, S; Henry, E; Morgan, G; Westwater, D; Haley, JB; Henry, E;
Indirizzi:
Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Neurol, New Haven, CT 06510 USA Univ Rochester, Rochester, NY USA Univ Rochester Rochester NY USAUniv Rochester, Rochester, NY USA Toronto Western Hosp, Toronto, ON M5T 2S8, Canada Toronto Western Hosp Toronto ON Canada M5T 2S8 oronto, ON M5T 2S8, Canada
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 57, anno: 2001, supplemento:, 3
pagine: S52 - S59
SICI:
0028-3878(200111)57:10<S52:AMAODT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON EMISSION TOMOGRAPHY; ESSENTIAL TREMOR; DISEASE; SPECT; IODINE-123-BETA-CIT; DIAGNOSIS; STRIATUM; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Marek, K Yale Univ, Sch Med, Dept Neurol, 40 Temple St,Suite 6C, New Haven, CT 06510 USA Yale Univ 40 Temple St,Suite 6C New Haven CT USA 06510 06510 USA
Citazione:
K. Marek et al., "A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPELT in parkinsonism", NEUROLOGY, 57(10), 2001, pp. S52-S59

Abstract

Background: In vivo imaging of the dopamine transporter (DAT) with SPELT is a quantitative biomarker for PD onset and severity. Objective: To use a multicenter study to evaluate the diagnostic accuracy of DOPASCAN and SPELT in patients with PD, progressive supranuclear palsy (PSP), and essential tremor (ET), and in healthy controls (HC). Methods: Ninety-six individuals with known clinical diagnosis were imaged with DOPASCAN at five sites with different multidetector SPELT systems. Both masked visual interpretation and region of interest (ROI) analysis were performed at each site and at a coreanalysis center. Results: Visual interpretation of the images by an expertpanel demonstrated a sensitivity of 0.98 and specificity of 0.83 comparingparkinsonian (PD + PSP) versus nonparkinsonian (ET + HC) controls. Quantitative analysis of putamen and caudate DOPASCAN uptake for each region in the PD or PSP groups was significantly reduced compared to the ET or HC groups. Comparison of parkinsonian (PD + PSP) versus nonparkinsonian (ET + HC) individuals demonstrated a reduction of 76% in mean putamen and 48% in mean caudate DOPASCAN uptake. Conclusions: DOPASCAN and SPELT imaging reliably and effectively distinguish between subjects with Parkinson's syndrome (PD PSP) and without Parkinson's syndrome (HC + ET). This is the first multicenter assessment of dopamine transporter imaging demonstrating that this tool may be used widely to assess dopaminergic degeneration in patients with parkinsonism.

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Documento generato il 19/01/20 alle ore 09:19:49