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Titolo:
Differential effects of D-1 and D-2 agonists in MPTP,treated primates: Functional implications for Parkinson's disease
Autore:
Boyce, S; Rupniak, NMJ; Steventon, MJ; Iversen, SD;
Indirizzi:
Merck Sharp & Dohme Ltd, Res Labs, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Harlow Essex England CM20 2QR 2QR, Essex, England
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 57, anno: 2001, supplemento:, 3
pagine: S27 - S33
SICI:
0028-3878(200111)57:10<S27:DEODAD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-TREATED MARMOSET; DOPAMINE RECEPTOR; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; ANTIPARKINSONIAN ACTIVITY; INDUCED DYSKINESIA; D1; MONKEYS; BROMOCRIPTINE; BEHAVIOR; LEVODOPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Boyce, S Merck Sharp & Dohme Ltd, Res Labs, Neurosci Res Ctr, Terlings Pk,Eastwick Rd, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Terlings Pk,Eastwick Rd Harlow Essex England CM20 2QR
Citazione:
S. Boyce et al., "Differential effects of D-1 and D-2 agonists in MPTP,treated primates: Functional implications for Parkinson's disease", NEUROLOGY, 57(10), 2001, pp. S27-S33

Abstract

Administration of the indirect agonist L-dopa, the nonselective direct agonist apomorphine, or the selective D-2 agonist (+)-PHNO, reversed parkinsonism and induced locomotor activation in MPTP-treated squirrel monkeys. In contrast, administration of the selective partial D-1 agonist SKF38393 did not induce locomotor activity, but rather decreased activity. Choreiform movements were observed only following treatment with L-dopa. Coadministrationof the D-1 antagonist SCH23390 prevented L-dopa-induced chorea at the timeof peak effect. However, a rebound exaggeration of chorea was observed following SCH23390 at the time when chorea induced by L-dopa alone would normally be subsiding. Unlike chorea, dystonia could be induced by treatment with either L-dopa or (+)-PHNO. Administration of apomorphine failed to significantly induce dystonia, although a small increase was observed with the highest dose. Treatment with SKF38393 actually decreased dystonia. Our findings clearly indicate that D-2 receptor stimulation appears essential for antiparkinsonian activity, and also implicate D-2 receptors in the genesis of dystonia, but not chorea. D-1 receptor stimulation appears to be involved in the genesis of chorea and possibly also dystonia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:52:10