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Titolo:
The immunological synapse and CD28-CD80 interactions
Autore:
Bromley, SK; Iaboni, A; Davis, SJ; Whitty, A; Green, JM; Shaw, AS; Weiss, A; Dustin, ML;
Indirizzi:
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Med, Div Rheumatol,San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA Washington Univ St Louis MO USA Dept Pathol & Immunol, St Louis, MO USA Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 d, Dept Med, St Louis, MO 63110 USA Univ Oxford, Nuffield Dept Med, Oxford, England Univ Oxford Oxford England v Oxford, Nuffield Dept Med, Oxford, England Biogen Inc, Cambridge, MA 02142 USA Biogen Inc Cambridge MA USA 02142Biogen Inc, Cambridge, MA 02142 USA NYU, Sch Med, Dept Pathol, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Pathol, New York, NY USA NYU, Sch Med, Program Mol Pathogenesis, New York, NY USA NYU New York NY USA Sch Med, Program Mol Pathogenesis, New York, NY USA Skirball Inst Biomol Med, New York, NY USA Skirball Inst Biomol Med New York NY USA st Biomol Med, New York, NY USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 12, volume: 2, anno: 2001,
pagine: 1159 - 1166
SICI:
1529-2908(200112)2:12<1159:TISACI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; NF-KAPPA-B; MONOCLONAL-ANTIBODIES; ANTIGEN RECOGNITION; LOW-AFFINITY; CD28; RECEPTOR; ADHESION; COSTIMULATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Dustin, ML Univ Calif San Francisco, Howard Hughes Med Inst, Dept Med, DivRheumatol,San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
S.K. Bromley et al., "The immunological synapse and CD28-CD80 interactions", NAT IMMUNOL, 2(12), 2001, pp. 1159-1166

Abstract

According to the two-signal model of T cell activation, costimulatory molecules augment T cell receptor (TCR) signaling, whereas adhesion molecules enhance TCR-MHC-peptide recognition. The structure and binding properties ofCD28 imply that it may perform both functions, blurring the distinction between adhesion and costimulatory molecules. Our results show that CD28 on naive T cells does not support adhesion and has little or no capacity for directly enhancing TCR-MHC-peptide interactions. Instead of being dependent on costimulatory signaling, we propose that a key function of the immunological synapse is to generate a cellular microenvironment that favors the interactions of potent secondary signaling molecules, such as CD28.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:45:52