Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dermal-resident CD14(+) cells: differentiate into Langerhans cells
Autore:
Larregina, AT; Morelli, AE; Spencer, LA; Logar, AJ; Watkins, SC; Thomson, AW; Falo, LD;
Indirizzi:
Univ Pittsburgh, Med Ctr, Dept Dermatol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 ermatol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 nc Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 at Inst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Surg, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 pt Surg, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Physiol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Physiol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Ctr Biol Imaging, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Imaging, Pittsburgh, PA 15213 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 12, volume: 2, anno: 2001,
pagine: 1151 - 1158
SICI:
1529-2908(200112)2:12<1151:DCCDIL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; NECROSIS-FACTOR-ALPHA; NORMAL HUMAN-SKIN; DENDRITIC CELLS; T-LYMPHOCYTES; IN-VITRO; GENERATION; MIGRATION; ANTIGENS; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Larregina, AT Univ Pittsburgh, Med Ctr, Dept Dermatol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 burgh, PA 15213 USA
Citazione:
A.T. Larregina et al., "Dermal-resident CD14(+) cells: differentiate into Langerhans cells", NAT IMMUNOL, 2(12), 2001, pp. 1151-1158

Abstract

Epidermal Langerhans cells (LCs) show extraordinary immunostimulatory capacity and play a key role in the initiation and regulation of immune responses. Studies of LC biology are currently the focus of efforts to engineer immune responses and to better understand the immunopathology of cutaneous diseases. Here we identified and characterized a population of LC precursors that were resident in human skin. These immediate precursors expressed CD14, langerin and functional CCR6. When cultured with transforming growth factor-beta1 alone, they had the potential to differentiate into epidermal LCs;when cultured in the presence of granulocyte macrophage-colony-stimulatingfactor and interleukin 4 they differentiated into functionally mature dendritic cells. Identification and characterization of these LC precursors provided insight into LC biology and the mechanism(s) through which LCs repopulate the epidermis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:34:00