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Titolo:
Plasma cells: finding new light at the end of B cell development
Autore:
Calame, KL;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 12, volume: 2, anno: 2001,
pagine: 1103 - 1108
SICI:
1529-2908(200112)2:12<1103:PCFNLA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON REGULATORY FACTOR-4; GERMINAL-CENTER FORMATION; ANTIBODY-SECRETING CELLS; TRANSCRIPTION FACTOR; TERMINAL DIFFERENTIATION; GENE-EXPRESSION; IMMUNE-RESPONSE; MARGINAL ZONE; IN-VIVO; MEMORY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Calame, KL Columbia Univ Coll Phys & Surg, Dept Microbiol, 630 W 168th St,New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St New York NY USA 10032
Citazione:
K.L. Calame, "Plasma cells: finding new light at the end of B cell development", NAT IMMUNOL, 2(12), 2001, pp. 1103-1108

Abstract

Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptiveimmunity. Although intense effort has been devoted to studying the regulation and requirements for early B cell development, little information has been available on plasma cells. However, more recent work-including studies on genetically altered mice and data from microarray analyses-has begun to identify the regulatory cascades that initiate and maintain the plasma cellphenotype. This review will summarize our current understanding of the molecules that regulate commitment to a plasma cell fate and those that mediate plasma cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:15:23