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Titolo:
Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism
Autore:
Larson-Meyer, DE; Newcomer, BR; Hunter, GR; Joanisse, DR; Weinsier, RL; Bamman, MM;
Indirizzi:
Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USALouisiana State Univ Baton Rouge LA USA 70808 , Baton Rouge, LA 70808 USA Univ Alabama, Dept Crit & Diagnost Care, Birmingham, AL USA Univ Alabama Birmingham AL USA Crit & Diagnost Care, Birmingham, AL USA Univ Alabama, Dept Human Studies, Birmingham, AL USA Univ Alabama Birmingham AL USA a, Dept Human Studies, Birmingham, AL USA Univ Laval, Dept Social & Prevent Med, Phys Act Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 t Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Alabama, Dept Nutr Sci, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 t Nutr Sci, Birmingham, AL 35294 USA
Titolo Testata:
MUSCLE & NERVE
fascicolo: 12, volume: 24, anno: 2001,
pagine: 1665 - 1676
SICI:
0148-639X(200112)24:12<1665:RBIVAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; MAXIMAL OXYGEN-UPTAKE; MITOCHONDRIAL-FUNCTION; P-31 MRS; ELECTRICAL-STIMULATION; PRODUCTION-RATES; ENZYME-ACTIVITY; FORCE-LEVEL; FIBER TYPE; IN-VIVO;
Keywords:
calf muscle; citochrome c oxidase; citrate synthase; mitochondrial function; oxidative metabolism; P-31 MRS; skeletal muscle fiber type;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Larson-Meyer, DE Louisiana State Univ, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA Louisiana State Univ 6400 Perkins Rd Baton Rouge LA USA 70808
Citazione:
D.E. Larson-Meyer et al., "Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism", MUSCLE NERV, 24(12), 2001, pp. 1665-1676

Abstract

The relationships between in vivo P-31 magnetic resonance spectroscopy (MRS) and in vitro markers of oxidative capacity (mitochondrial function) weredetermined in 27 women with varying levels of physical fitness. Following 90-s isometric plantar flexion exercises, calf muscle mitochondrial function was determined from the phosphocreatine (PCr) recovery time constant, theadenosine diphosphate (ADP) recovery time constant, the rate of change of PCr during the initial 14 s of recovery, and the apparent maximum rate of oxidative adenosine triphosphate (ATP) synthesis (Q(max)). Muscle fiber typedistribution (I, IIa, IIx), citrate synthase (CS) activity, and cytochromec oxidase (COX) activity were determined from a biopsy sample of lateral gastrocnemius. MRS markers of mitochondrial function correlated moderately (P < 0.05) with the percentage of type IIa oxidative fibers (r = 0.41 to 0.66) and CS activity (r = 0.48 to 0.64), but only weakly with COX activity (r= 0.03 to 0.26, P > 0.05). These results support the use of MRS to determine mitochondrial function in vivo. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:56:11