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Titolo:
Computer simulation of jitter phenomenon in neuromuscular transmission disorders
Autore:
Miralles, F;
Indirizzi:
Hosp Univ Son Dureta, Serv Neurol, Unitat Patol Neuromuscular, Palma de Mallorca 07014, Spain Hosp Univ Son Dureta Palma de Mallorca Spain 07014 Mallorca 07014, Spain
Titolo Testata:
MUSCLE & NERVE
fascicolo: 12, volume: 24, anno: 2001,
pagine: 1635 - 1646
SICI:
0148-639X(200112)24:12<1635:CSOJPI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-FIBER ELECTROMYOGRAPHY; TRANSMITTER RELEASE; MYASTHENIA-GRAVIS; SODIUM-CHANNELS; QUANTAL RELEASE; TWITCH MUSCLES; SAFETY FACTOR; SLOW-TWITCH; TEMPERATURE; JUNCTION;
Keywords:
computer simulation; jitter; mammalian neuromuscular junction; safety factor; single-fiber electromyography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Miralles, F Hosp Univ Son Dureta, Serv Neurol, Unitat Patol Neuromuscular,C Andrea Doria 55, Palma de Mallorca 07014, Spain Hosp Univ Son Dureta C Andrea Doria 55 Palma de Mallorca Spain 07014
Citazione:
F. Miralles, "Computer simulation of jitter phenomenon in neuromuscular transmission disorders", MUSCLE NERV, 24(12), 2001, pp. 1635-1646

Abstract

Neuromuscular jitter is a sensitive measure of the safety factor of neuromuscular transmission. Nevertheless, the actual relationship between jitter and the safety factor is unknown because these parameters have not been simultaneously measured. In order to explore the theoretical relationship between them, a computer model of mammalian neuromuscular transmission has beendeveloped. If the safety factor is expressed as the absolute value of the natural logarithm of the probability of a block, the model predicts a double exponential relationship between the safety factor and jitter, except when the percentage of blocks is greater than 90%. In that case, the jitter value decreases. Simulation of acetylcholinesterase inhibition shows that this treatment decreases the neuromuscular transmission blocks more effectively in postsynaptic than in presynaptic disorders. In contrast, when the percentage of blocks is greater than 60%, the jitter value increases in both conditions. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:26:50