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Titolo:
Rigidity decreases resting tremor intensity in Parkinson's disease: A [I-123]beta-CIT SPECT study in early, nonmedicated patients
Autore:
Winogrodzka, A; Wagenaar, RC; Bergmans, P; Vellinga, A; Booij, J; van Royen, EA; van Emmerik, REA; Stoof, JC; Wolters, EC;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Neurol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Dept Phys Therapy, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 ercise Sci, Amherst, MA 01003 USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 6, volume: 16, anno: 2001,
pagine: 1033 - 1040
SICI:
0885-3185(200111)16:6<1033:RDRTII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; STRIATAL DOPAMINE TRANSPORTERS; BINDING; DYNAMICS; SYSTEM; GAIT;
Keywords:
Parkinson's disease; resting tremor; rigidity; spectral analysis; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Winogrodzka, A Free Univ Amsterdam Hosp, Dept Neurol, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
A. Winogrodzka et al., "Rigidity decreases resting tremor intensity in Parkinson's disease: A [I-123]beta-CIT SPECT study in early, nonmedicated patients", MOVEMENT D, 16(6), 2001, pp. 1033-1040

Abstract

Tremor is one of the clinical hallmarks of Parkinson's disease (PD). Although it is accepted that other classic symptoms of PD such as rigidity and bradykinesia result from a degeneration of the nigrostriatal system and subsequent reduction in striatal dopamine, the pathophysiology of resting tremor remains unclear. The majority of recent single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies, using various radioligands, demonstrated significant correlation between striatal radioligand bindings and the degree of parkinsonian symptoms such as rigidityand bradykinesia, but not tremor. We investigate the relationship between the degeneration of the nigrostriatal pathway and the appearance of restingtremor, taking into account the possible interference of rigidity with theresting tremor. Thirty early and drug-naive PD patients were examined. Tremor and rigidity of the arms were assessed using UPDRS, and the power of tremor was estimated using spectral analysis of tremor peaks. [I-123]beta -CIT SPECT was used to assess degeneration of the dopaminergic system in PD patients. A comparison between asymmetry indices showed that in terms of bothtremor and rigidity, the most affected arm corresponded significantly withthe contralateral striatum, having the largest reduction in radioligand binding. Furthermore, tremor power accounted for a significant part of variance in the contralateral striatum, suggesting a relationship between this PDsymptom and the degeneration of the dopaminergic system. Further, the degree of tremor was reduced with increasing rigidity. However, correcting for the influence of rigidity, the significant contribution of tremor in the variance in the contralateral striatal [I-123]beta -CIT binding disappeared. When the confounding influence of rigidity is taken into account, no significant direct relationship between dopaminergic degeneration and the degree of tremor could be found. Other pathophysiological mechanisms should be similarly investigated in order to further our understanding of the origin of resting tremor in PD. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:30:32