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Titolo:
[I-123]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy
Autore:
Varrone, A; Marek, KL; Jennings, D; Innis, RB; Seibyl, JP;
Indirizzi:
Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Neurol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Vet Adm Connecticut, West Haven, CT USA Vet Adm Connecticut West Haven CTUSA dm Connecticut, West Haven, CT USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 6, volume: 16, anno: 2001,
pagine: 1023 - 1032
SICI:
0885-3185(200111)16:6<1023:[SIDRD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; PROGRESSIVE SUPRANUCLEAR PALSY; STRIATONIGRAL DEGENERATION; IODINE-123-BETA-CIT SPECT; DIFFERENTIAL-DIAGNOSIS; CLINICAL-FEATURES; NATURAL-HISTORY; BINDING; PET;
Keywords:
movement disorders; substantia nigra; basal ganglia; neurodegeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Varrone, A Univ Naples Federico II, Dipartimento Diagnost Immagini & Radioterapia, Via S Pansini 5, I-80131 Naples, Italy Univ Naples Federico II ViaS Pansini 5 Naples Italy I-80131 y
Citazione:
A. Varrone et al., "[I-123]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy", MOVEMENT D, 16(6), 2001, pp. 1023-1032

Abstract

In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPELT) is a quantitative biomarker for Parkinson'sdisease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [I-123]beta -CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [I-123]beta -CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSApatients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSAand PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:01:03