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Titolo:
Synthetic phosphoantigens enhance human V gamma 9V delta 2 T lymphocytes killing of non-Hodgkin's B lymphoma
Autore:
Sicard, H; Al Saati, T; Delsol, G; Fournie, JJ;
Indirizzi:
CHU Purpan, Reponse Immunitaire & CMH, INSERM U395, F-31024 Toulouse, France CHU Purpan Toulouse France F-31024 INSERM U395, F-31024 Toulouse, France CHU Purpan, Lab Anat & Pathol, Toulouse, France CHU Purpan Toulouse France Purpan, Lab Anat & Pathol, Toulouse, France
Titolo Testata:
MOLECULAR MEDICINE
fascicolo: 10, volume: 7, anno: 2001,
pagine: 711 - 722
SICI:
1076-1551(200110)7:10<711:SPEHVG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPEPTIDIC MYCOBACTERIAL LIGANDS; KILLER INHIBITORY RECEPTORS; PULSED DENDRITIC CELLS; FOLLICULAR LYMPHOMA; TUMOR-IMMUNITY; IN-VITRO; COSTIMULATORY MOLECULES; ANTITUMOR IMMUNITY; MULTIPLE-MYELOMA; CYTOTOXIC-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Sicard, H CHU Purpan, Reponse Immunitaire & CMH, INSERM U395, BP3028, F-31024 Toulouse, France CHU Purpan BP3028 Toulouse France F-31024 1024 Toulouse, France
Citazione:
H. Sicard et al., "Synthetic phosphoantigens enhance human V gamma 9V delta 2 T lymphocytes killing of non-Hodgkin's B lymphoma", MOL MED, 7(10), 2001, pp. 711-722

Abstract

Background: Non-Hodgkin's B lymphomas (NI-IL) are often resistant to conventional treatments and, until now, immunotherapeutic approaches against NHLonly aimed at inducing alpha beta anti-tumor effectors. Nevertheless, human blood V gamma 9V delta2 T lymphocytes represent an abundant pool of cytotoxic tumor-reactive cells. V gamma 9V delta2 T cells are strongly activatedby natural compounds, from which powerful synthetic ligands have been derived. These synthetic antigens induce efficient V gamma 9V delta2 T cell responses in vitro. Materials and Methods: We set up a series of V gamma 9V delta2 T cell-activation experiments, including cytotoxic activity and amplification from whole blood cells. Several types of V gamma 9V delta2 effectors were challenged against a panel of 16 B lymphoma cell lines. These tests have been performed in the absence and presence of gamma delta -speciflc synthetic ligands to evaluate the effect of such molecules on gamma delta anti-tumor activity. Results: We report here that V gamma 9V delta2 T cells recognize B lymphomas. This recognition is associated with the cytotoxic activity against B-lymphoma cells and/or proliferative responses, and appears to be T-cell antigen receptor (TCR) -dependent. Because few B lymphoma induce a complete set of V gamma 9V delta2 cell responses, a chemical ligand of V gamma 9V delta2T cells was used to enhance both proliferation and cytotoxic activity of anti-B lymphoma effectors. We show that such synthetic compound improves V gamma 9V delta2 CTL numbers and lysis of B lymphoma lines, especially when the targets are already spontaneously recognized by these effectors. Conclusions: We report here that human V gamma 9V delta2 T cells anti-B lymphoma response can be improved by use of specific synthetic ligands, whichenhance their cytotoxic activity and allows their rapid expansion ex vivo.

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Documento generato il 05/12/20 alle ore 07:36:00