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Titolo:
RIM4 encodes a meiotic activator required for early events of meiosis in Saccharomyces cerevisiae
Autore:
Deng, C; Saunders, WS;
Indirizzi:
Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 iol Sci, Pittsburgh, PA 15260 USA
Titolo Testata:
MOLECULAR GENETICS AND GENOMICS
fascicolo: 3, volume: 266, anno: 2001,
pagine: 497 - 504
SICI:
1617-4615(200111)266:3<497:REAMAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE; GENE-PRODUCT; DNA-REPLICATION; HIV-1 TAT; YEAST; SPORULATION; IME2; RECOMBINATION; STIMULATION; EXPRESSION;
Keywords:
Saccharomyces cerevisiae; meiosis; DNA synthesis; IME2; RIM4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Saunders, WS Univ Pittsburgh, Dept Biol Sci, 258 Crawford Hall, Pittsburgh, PA 15260 USA Univ Pittsburgh 258 Crawford Hall Pittsburgh PA USA 15260 USA
Citazione:
C. Deng e W.S. Saunders, "RIM4 encodes a meiotic activator required for early events of meiosis in Saccharomyces cerevisiae", MOL GENET G, 266(3), 2001, pp. 497-504

Abstract

RIM4 was previously found to be required for both the IME1- and IME2-dependent pathways of meiotic gene expression in Saccharomyces cerevisiae. We now demonstrate that RIM4 is also required for meiotic division and recombination. Furthermore, rim4 Delta mutants show defects in premeiotic DNA synthesis, which can be suppressed by deletion of the SIC1 gene, which encodes a Cdk inhibitor. Expression of RIM4 is induced early in meiosis, and is dependent on IME1 but not IME2. Indeed, RIM4 itself is essential for the meioticexpression of IME2. These results suggest that RIM4 is epistatic to IME2, and is required for multiple steps during sporulation. In agreement with this interpretation, overexpression of RIM4 induces low levels of sporulationin rich medium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:26:20