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Titolo:
USPIO-enhanced dynamic MRI: Evaluation of normal and transplanted rat kidneys
Autore:
Yang, DW; Ye, Q; Williams, M; Sun, Y; Hu, TCC; Williams, DS; Moura, JMF; Ho, C;
Indirizzi:
Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh NMR Ctr Biomed Res, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 es, Pittsburgh, PA 15213 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 6, volume: 46, anno: 2001,
pagine: 1152 - 1163
SICI:
0740-3194(200112)46:6<1152:UDMEON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; ACUTE TUBULAR-NECROSIS; RENAL-ALLOGRAFTS; CONTRAST AGENTS; MACROPHAGE INFILTRATION; GD-DTPA; REJECTION; PARTICLES; COMPLICATIONS; PERFUSION;
Keywords:
kidney; transplanted rat kidney; dynamic magnetic resonance imaging; MRI contrast agents; ultrasmall superparamagnetic iron oxide (USPIO) particles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ho, C Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh NMR Ctr Biomed Res, 4400 5th Ave, Pittsburgh, PA 15213 USA Carnegie Mellon Univ 4400 5th Ave Pittsburgh PA USA 15213 15213 USA
Citazione:
D.W. Yang et al., "USPIO-enhanced dynamic MRI: Evaluation of normal and transplanted rat kidneys", MAGN RES M, 46(6), 2001, pp. 1152-1163

Abstract

To evaluate first-pass renal perfusion with ultrasmall superparamagnetic iron oxide (USPIO) particles by MRI, 40 normal rats (20 Dark Agouti (DA) rats and 20 Brown Norway (BN) rats) and 16 transplanted rats (12 allografts and four isografts) were studied on day 4 post-transplantation with differentUSPIO doses (3.0-18.1 mg Fe/kg/body weight). All animals underwent 128 consecutive snapshot fast low-angle shot (FLASH) coronal dynamic studies in 43s. In the normal rats, a larger maximum signal decrease (MSD) in the cortex and the outer medulla is observed with an increasing dose of USPIO particles (P < 0.01). No significant differences were observed between the right and left kidneys at all doses studied. Higher MSD, time of occurrence of MSD (t(MSD)), and wash-in slope appear with higher doses of USPIO particles. The dynamic curves for DA rats show similar shapes when compared to those for BN rats. In the transplanted rats, allograft kidneys show lower MSD, longer t(MSD), and lower wash-in slope compared to those in the normal kidneys. Isograft kidneys show perfusion patterns similar to those of normal kidneys in the cortex and the outer medulla. Histopathology indicates acute vascular rejection in all allografts and normal kidney architecture in all isografts. The results clearly show good agreement between the renal graft perfusion measurements and histopathological changes associated with rejection. This work also introduces a new signal analysis methodology for the automatic detection of transplanted organ rejection. This method compares the dynamics of the intrarenal signal intensities for native and transplanted kidneys. A quantitative measurement to detect significant differences between these signals was developed, and showed that this technique exhibits good performance in identifying renal rejection. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 10/04/20 alle ore 01:20:06